Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation

Hsp70 is a key molecular chaperone in the protein quality control system to safeguard protein homeostasis in cells. Previous studies have shown that Hsp70 chaperones TDP-43, a pathogenic protein associated with amyotrophic lateral sclerosis (ALS), in nuclear bodies and prevents it from the pathologi...

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Detalles Bibliográficos
Autores principales: Li, Yichen, Gu, Jinge, Wang, Chen, Hu, Jiaojiao, Zhang, Shenqing, Liu, Cong, Zhang, Shengnan, Fang, Yanshan, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127583/
https://www.ncbi.nlm.nih.gov/pubmed/35620440
http://dx.doi.org/10.1016/j.isci.2022.104356

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