Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury

The therapeutic use of RNAi has grown but often faces several hurdles related to delivery systems, compound stability, immune activation, and on-target/off-tissue effects. Self-delivering RNAi (sdRNA) molecules do not require delivery agents or excipients. Here we demonstrate the ability of sdRNA to...

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Detalles Bibliográficos
Autores principales: Woller, Sarah A., Ruschel, Joerg, Morquette, Barbara, Cardia, James, Yan, Dinxue, Holton, Katherine, Shmushkovich, Taisia, Niederst, Emily, Bulock, Karen, Wolfson, Alexey, Abbinanti, Matthew, Fournier, Alyson E., McKerracher, Lisa, Rosen, Kenneth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127586/
https://www.ncbi.nlm.nih.gov/pubmed/35620420
http://dx.doi.org/10.1016/j.isci.2022.104379

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