Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis

Atypical hemolytic uremic syndrome (aHUS) is a disease associated with dysregulation of the immune complement system, especially of the alternative pathway (AP). Complement factor H (CFH), consisting of 20 domains called complement control protein (CCP1-20), downregulates the AP as a cofactor for me...

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Detalles Bibliográficos
Autores principales: Yokoo, Takanori, Tanabe, Aki, Yoshida, Yoko, Caaveiro, Jose M.M., Nakakido, Makoto, Ikeda, Yoichiro, Fujimura, Yoshihiro, Matsumoto, Masaneori, Entzminger, Kevin, Maruyama, Toshiaki, Okumura, C.J., Nangaku, Masaomi, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127587/
https://www.ncbi.nlm.nih.gov/pubmed/35452676
http://dx.doi.org/10.1016/j.jbc.2022.101962

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