Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

Basal cell carcinomas (BCCs) frequently possess immense mutational burdens; however, the functional significance of most of these mutations remains unclear. Here, we report that loss of Ptch1, the most common mutation that activates upstream Hedgehog (Hh) signaling, initiates the formation of nascen...

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Detalles Bibliográficos
Autores principales: Trieu, Kenneth G., Tsai, Shih-Ying, Eberl, Markus, Ju, Virginia, Ford, Noah C., Doane, Owen J., Peterson, Jamie K., Veniaminova, Natalia A., Grachtchouk, Marina, Harms, Paul W., Swartling, Fredrik J., Dlugosz, Andrzej A., Wong, Sunny Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127636/
https://www.ncbi.nlm.nih.gov/pubmed/35508126
http://dx.doi.org/10.1016/j.celrep.2022.110779

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