Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity

[Image: see text] Type 2 diabetes is marked by progressive β-cell failure, leading to loss of β-cell mass. Increased levels of circulating glucose and free fatty acids associated with obesity lead to β-cell glucolipotoxicity. There are currently no therapeutic options to address this facet of β-cell...

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Detalles Bibliográficos
Autores principales: Small, Jonnell C., Joblin-Mills, Aidan, Carbone, Kaycee, Kost-Alimova, Maria, Ayukawa, Kumiko, Khodier, Carol, Dancik, Vlado, Clemons, Paul A., Munkacsi, Andrew B., Wagner, Bridget K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127801/
https://www.ncbi.nlm.nih.gov/pubmed/35439415
http://dx.doi.org/10.1021/acschembio.2c00052

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