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MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis
OBJECTIVE: The methionine synthase reductase (MTRR) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. METHODS: We...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127855/ https://www.ncbi.nlm.nih.gov/pubmed/35579185 http://dx.doi.org/10.1177/03000605221097486 |
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author | Zhong, Guping Luo, Xiaojin Li, Ji Liao, Yuanhang Gui, Guan Sheng, Jianwen |
author_facet | Zhong, Guping Luo, Xiaojin Li, Ji Liao, Yuanhang Gui, Guan Sheng, Jianwen |
author_sort | Zhong, Guping |
collection | PubMed |
description | OBJECTIVE: The methionine synthase reductase (MTRR) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. METHODS: We performed a comprehensive and systematic search of PubMed, Google Scholar, MEDLINE, Science Direct, Scopus, CNKI, and Web of Science. Five studies were included in this meta-analysis to determine whether MTRR rs1532268 polymorphism contributes to the risk of GC. RESULTS: Pooled data indicated that the MTRR rs1532268 polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01–1.29) and dominant model (OR = 1.14, 95% CI = 1.00–1.30). In the analysis stratified by ethnicity, no relationship was found in Whites or Asians. CONCLUSION: Our meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and GC development. |
format | Online Article Text |
id | pubmed-9127855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91278552022-05-25 MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis Zhong, Guping Luo, Xiaojin Li, Ji Liao, Yuanhang Gui, Guan Sheng, Jianwen J Int Med Res Meta Analysis OBJECTIVE: The methionine synthase reductase (MTRR) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. METHODS: We performed a comprehensive and systematic search of PubMed, Google Scholar, MEDLINE, Science Direct, Scopus, CNKI, and Web of Science. Five studies were included in this meta-analysis to determine whether MTRR rs1532268 polymorphism contributes to the risk of GC. RESULTS: Pooled data indicated that the MTRR rs1532268 polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01–1.29) and dominant model (OR = 1.14, 95% CI = 1.00–1.30). In the analysis stratified by ethnicity, no relationship was found in Whites or Asians. CONCLUSION: Our meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and GC development. SAGE Publications 2022-05-17 /pmc/articles/PMC9127855/ /pubmed/35579185 http://dx.doi.org/10.1177/03000605221097486 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Meta Analysis Zhong, Guping Luo, Xiaojin Li, Ji Liao, Yuanhang Gui, Guan Sheng, Jianwen MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
title | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
title_full | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
title_fullStr | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
title_full_unstemmed | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
title_short | MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
title_sort | mtrr rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis |
topic | Meta Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127855/ https://www.ncbi.nlm.nih.gov/pubmed/35579185 http://dx.doi.org/10.1177/03000605221097486 |
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