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Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism

[Image: see text] In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal wo...

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Autores principales: Blanco-Morales, Virginia, Silvestre, Ramona de los Ángeles, Hernández-Álvarez, Elena, Donoso-Navarro, Encarnación, Alegría, Amparo, Garcia-Llatas, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127961/
https://www.ncbi.nlm.nih.gov/pubmed/35012310
http://dx.doi.org/10.1021/acs.jafc.1c06120
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author Blanco-Morales, Virginia
Silvestre, Ramona de los Ángeles
Hernández-Álvarez, Elena
Donoso-Navarro, Encarnación
Alegría, Amparo
Garcia-Llatas, Guadalupe
author_facet Blanco-Morales, Virginia
Silvestre, Ramona de los Ángeles
Hernández-Álvarez, Elena
Donoso-Navarro, Encarnación
Alegría, Amparo
Garcia-Llatas, Guadalupe
author_sort Blanco-Morales, Virginia
collection PubMed
description [Image: see text] In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal women who intook a PS-enriched (2 g PS/day) or PS–GOS-enriched beverage (2 g PS/day and 4.3 g GOS/day) for 6 weeks. The presence of GOS did not modify the hypocholesterolemic effect of the PS-enriched beverage (total- and low-density lipoprotein-cholesterol reductions) or sterol bioavailability (increments of serum markers of dietary PS intake and of cholesterol synthesis). The consumption of both beverages led to an increase of sterol and metabolite excretion (with the exception of coprostanol, which decreased) and to slight changes in women’s capacities for sterol conversion, regardless of the GOS presence. This study demonstrates the suitability of simultaneous enrichment with PS and GOS in milk-based fruit beverages, considering their hypocholesterolemic effect.
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spelling pubmed-91279612022-05-25 Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism Blanco-Morales, Virginia Silvestre, Ramona de los Ángeles Hernández-Álvarez, Elena Donoso-Navarro, Encarnación Alegría, Amparo Garcia-Llatas, Guadalupe J Agric Food Chem [Image: see text] In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal women who intook a PS-enriched (2 g PS/day) or PS–GOS-enriched beverage (2 g PS/day and 4.3 g GOS/day) for 6 weeks. The presence of GOS did not modify the hypocholesterolemic effect of the PS-enriched beverage (total- and low-density lipoprotein-cholesterol reductions) or sterol bioavailability (increments of serum markers of dietary PS intake and of cholesterol synthesis). The consumption of both beverages led to an increase of sterol and metabolite excretion (with the exception of coprostanol, which decreased) and to slight changes in women’s capacities for sterol conversion, regardless of the GOS presence. This study demonstrates the suitability of simultaneous enrichment with PS and GOS in milk-based fruit beverages, considering their hypocholesterolemic effect. American Chemical Society 2022-01-11 2022-01-19 /pmc/articles/PMC9127961/ /pubmed/35012310 http://dx.doi.org/10.1021/acs.jafc.1c06120 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Blanco-Morales, Virginia
Silvestre, Ramona de los Ángeles
Hernández-Álvarez, Elena
Donoso-Navarro, Encarnación
Alegría, Amparo
Garcia-Llatas, Guadalupe
Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
title Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
title_full Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
title_fullStr Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
title_full_unstemmed Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
title_short Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
title_sort influence of galactooligosaccharides on the positive effect of plant sterol-enriched beverages on cardiovascular risk and sterol colon metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127961/
https://www.ncbi.nlm.nih.gov/pubmed/35012310
http://dx.doi.org/10.1021/acs.jafc.1c06120
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