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Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism
[Image: see text] In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal wo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127961/ https://www.ncbi.nlm.nih.gov/pubmed/35012310 http://dx.doi.org/10.1021/acs.jafc.1c06120 |
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author | Blanco-Morales, Virginia Silvestre, Ramona de los Ángeles Hernández-Álvarez, Elena Donoso-Navarro, Encarnación Alegría, Amparo Garcia-Llatas, Guadalupe |
author_facet | Blanco-Morales, Virginia Silvestre, Ramona de los Ángeles Hernández-Álvarez, Elena Donoso-Navarro, Encarnación Alegría, Amparo Garcia-Llatas, Guadalupe |
author_sort | Blanco-Morales, Virginia |
collection | PubMed |
description | [Image: see text] In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal women who intook a PS-enriched (2 g PS/day) or PS–GOS-enriched beverage (2 g PS/day and 4.3 g GOS/day) for 6 weeks. The presence of GOS did not modify the hypocholesterolemic effect of the PS-enriched beverage (total- and low-density lipoprotein-cholesterol reductions) or sterol bioavailability (increments of serum markers of dietary PS intake and of cholesterol synthesis). The consumption of both beverages led to an increase of sterol and metabolite excretion (with the exception of coprostanol, which decreased) and to slight changes in women’s capacities for sterol conversion, regardless of the GOS presence. This study demonstrates the suitability of simultaneous enrichment with PS and GOS in milk-based fruit beverages, considering their hypocholesterolemic effect. |
format | Online Article Text |
id | pubmed-9127961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91279612022-05-25 Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism Blanco-Morales, Virginia Silvestre, Ramona de los Ángeles Hernández-Álvarez, Elena Donoso-Navarro, Encarnación Alegría, Amparo Garcia-Llatas, Guadalupe J Agric Food Chem [Image: see text] In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal women who intook a PS-enriched (2 g PS/day) or PS–GOS-enriched beverage (2 g PS/day and 4.3 g GOS/day) for 6 weeks. The presence of GOS did not modify the hypocholesterolemic effect of the PS-enriched beverage (total- and low-density lipoprotein-cholesterol reductions) or sterol bioavailability (increments of serum markers of dietary PS intake and of cholesterol synthesis). The consumption of both beverages led to an increase of sterol and metabolite excretion (with the exception of coprostanol, which decreased) and to slight changes in women’s capacities for sterol conversion, regardless of the GOS presence. This study demonstrates the suitability of simultaneous enrichment with PS and GOS in milk-based fruit beverages, considering their hypocholesterolemic effect. American Chemical Society 2022-01-11 2022-01-19 /pmc/articles/PMC9127961/ /pubmed/35012310 http://dx.doi.org/10.1021/acs.jafc.1c06120 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Blanco-Morales, Virginia Silvestre, Ramona de los Ángeles Hernández-Álvarez, Elena Donoso-Navarro, Encarnación Alegría, Amparo Garcia-Llatas, Guadalupe Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and Sterol Colon Metabolism |
title | Influence of Galactooligosaccharides on the Positive
Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and
Sterol Colon Metabolism |
title_full | Influence of Galactooligosaccharides on the Positive
Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and
Sterol Colon Metabolism |
title_fullStr | Influence of Galactooligosaccharides on the Positive
Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and
Sterol Colon Metabolism |
title_full_unstemmed | Influence of Galactooligosaccharides on the Positive
Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and
Sterol Colon Metabolism |
title_short | Influence of Galactooligosaccharides on the Positive
Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk and
Sterol Colon Metabolism |
title_sort | influence of galactooligosaccharides on the positive
effect of plant sterol-enriched beverages on cardiovascular risk and
sterol colon metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127961/ https://www.ncbi.nlm.nih.gov/pubmed/35012310 http://dx.doi.org/10.1021/acs.jafc.1c06120 |
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