Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide

[Image: see text] Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2-cis-selective [2+2] glycosylation to generate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Njeri, Dancan K., Ragains, Justin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127968/
https://www.ncbi.nlm.nih.gov/pubmed/35522755
http://dx.doi.org/10.1021/acs.orglett.2c01034
_version_ 1784712465061249024
author Njeri, Dancan K.
Ragains, Justin R.
author_facet Njeri, Dancan K.
Ragains, Justin R.
author_sort Njeri, Dancan K.
collection PubMed
description [Image: see text] Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2-cis-selective [2+2] glycosylation to generate the fully protected tetrasaccharide was key to the success of this synthesis.
format Online
Article
Text
id pubmed-9127968
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-91279682022-05-25 Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide Njeri, Dancan K. Ragains, Justin R. Org Lett [Image: see text] Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2-cis-selective [2+2] glycosylation to generate the fully protected tetrasaccharide was key to the success of this synthesis. American Chemical Society 2022-05-06 2022-05-20 /pmc/articles/PMC9127968/ /pubmed/35522755 http://dx.doi.org/10.1021/acs.orglett.2c01034 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Njeri, Dancan K.
Ragains, Justin R.
Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
title Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
title_full Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
title_fullStr Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
title_full_unstemmed Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
title_short Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
title_sort total synthesis of an all-1,2-cis-linked repeating unit from the acinetobacter baumannii d78 capsular polysaccharide
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127968/
https://www.ncbi.nlm.nih.gov/pubmed/35522755
http://dx.doi.org/10.1021/acs.orglett.2c01034
work_keys_str_mv AT njeridancank totalsynthesisofanall12cislinkedrepeatingunitfromtheacinetobacterbaumanniid78capsularpolysaccharide
AT ragainsjustinr totalsynthesisofanall12cislinkedrepeatingunitfromtheacinetobacterbaumanniid78capsularpolysaccharide

Ejemplares similares