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Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern
The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Her...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127986/ https://www.ncbi.nlm.nih.gov/pubmed/35620108 http://dx.doi.org/10.3389/fmicb.2022.810576 |
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author | Raïch-Regué, Dàlia Muñoz-Basagoiti, Jordana Perez-Zsolt, Daniel Noguera-Julian, Marc Pradenas, Edwards Riveira-Muñoz, Eva Giménez, Neus Carabaza, Assumpta Giménez, Francesc Saludes, Verónica Martró, Elisa Robert, Neus Blanco, Ignacio Paredes, Roger Ruiz, Lidia Ballana, Ester Clotet, Bonaventura Blanco, Julià Izquierdo-Useros, Nuria |
author_facet | Raïch-Regué, Dàlia Muñoz-Basagoiti, Jordana Perez-Zsolt, Daniel Noguera-Julian, Marc Pradenas, Edwards Riveira-Muñoz, Eva Giménez, Neus Carabaza, Assumpta Giménez, Francesc Saludes, Verónica Martró, Elisa Robert, Neus Blanco, Ignacio Paredes, Roger Ruiz, Lidia Ballana, Ester Clotet, Bonaventura Blanco, Julià Izquierdo-Useros, Nuria |
author_sort | Raïch-Regué, Dàlia |
collection | PubMed |
description | The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Here, we found that the VOC diverge at the nucleocapsid protein used by four commercial Ag-RDTs for the viral detection. Relative to the original D614G variant, there was a 10-fold loss of detection for the Delta and Alpha variants in certain Ag-RDTs, a reduction above the threshold required to isolate the viable virus. However, Beta and Omicron variants did not lose the detection capacity. As the new VOC arise, successful contact tracing requires continuous monitoring of Ag-RDTs performance. |
format | Online Article Text |
id | pubmed-9127986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91279862022-05-25 Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern Raïch-Regué, Dàlia Muñoz-Basagoiti, Jordana Perez-Zsolt, Daniel Noguera-Julian, Marc Pradenas, Edwards Riveira-Muñoz, Eva Giménez, Neus Carabaza, Assumpta Giménez, Francesc Saludes, Verónica Martró, Elisa Robert, Neus Blanco, Ignacio Paredes, Roger Ruiz, Lidia Ballana, Ester Clotet, Bonaventura Blanco, Julià Izquierdo-Useros, Nuria Front Microbiol Microbiology The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Here, we found that the VOC diverge at the nucleocapsid protein used by four commercial Ag-RDTs for the viral detection. Relative to the original D614G variant, there was a 10-fold loss of detection for the Delta and Alpha variants in certain Ag-RDTs, a reduction above the threshold required to isolate the viable virus. However, Beta and Omicron variants did not lose the detection capacity. As the new VOC arise, successful contact tracing requires continuous monitoring of Ag-RDTs performance. Frontiers Media S.A. 2022-05-10 /pmc/articles/PMC9127986/ /pubmed/35620108 http://dx.doi.org/10.3389/fmicb.2022.810576 Text en Copyright © 2022 Raïch-Regué, Muñoz-Basagoiti, Perez-Zsolt, Noguera-Julian, Pradenas, Riveira-Muñoz, Giménez, Carabaza, Giménez, Saludes, Martró, Robert, Blanco, Paredes, Ruiz, Ballana, Clotet, Blanco and Izquierdo-Useros. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Raïch-Regué, Dàlia Muñoz-Basagoiti, Jordana Perez-Zsolt, Daniel Noguera-Julian, Marc Pradenas, Edwards Riveira-Muñoz, Eva Giménez, Neus Carabaza, Assumpta Giménez, Francesc Saludes, Verónica Martró, Elisa Robert, Neus Blanco, Ignacio Paredes, Roger Ruiz, Lidia Ballana, Ester Clotet, Bonaventura Blanco, Julià Izquierdo-Useros, Nuria Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern |
title | Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern |
title_full | Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern |
title_fullStr | Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern |
title_full_unstemmed | Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern |
title_short | Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern |
title_sort | performance of sars-cov-2 antigen-detecting rapid diagnostic tests for omicron and other variants of concern |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127986/ https://www.ncbi.nlm.nih.gov/pubmed/35620108 http://dx.doi.org/10.3389/fmicb.2022.810576 |
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