Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease. Whole-exome or genome sequencing can detect CHIP, but due to those as...

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Detalles Bibliográficos
Autores principales: Uddin, Md Mesbah, Zhou, Ying, Bick, Alexander G., Burugula, Bala Bharathi, Jaiswal, Siddhartha, Desai, Pinkal, Honigberg, Michael C., Love, Shelly-Ann, Barac, Ana, Hayden, Kathleen M., Manson, JoAnn E., Whitsel, Eric A., Kooperberg, Charles, Natarajan, Pradeep, Reiner, Alexander P., Kitzman, Jacob O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128083/
https://www.ncbi.nlm.nih.gov/pubmed/35610705
http://dx.doi.org/10.1186/s12979-022-00278-9

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