PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia‐like features

To examine effects of PP6 gene (Ppp6c) deficiency on pancreatic tumor development, we developed pancreas‐specific, tamoxifen‐inducible Cre‐mediated KP (KRAS(G12D) plus Trp53‐deficient) mice (cKP mice) and crossed them with Ppp6c(flox) (/) (flox) mice. cKP mice with the homozygous Ppp6c deletion deve...

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Detalles Bibliográficos
Autores principales: Fukui, Katsuya, Nomura, Miyuki, Kishimoto, Kazuhiro, Tanuma, Nobuhiro, Kurosawa, Koreyuki, Kanazawa, Kosuke, Kato, Hiroyuki, Sato, Tomoki, Miura, Shinji, Miura, Koh, Sato, Ikuro, Tsuji, Hiroyuki, Yamashita, Yoji, Tamai, Keiichi, Watanabe, Toshio, Yasuda, Jun, Tanaka, Takuji, Satoh, Kennichi, Furukawa, Toru, Jingu, Keiichi, Shima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128171/
https://www.ncbi.nlm.nih.gov/pubmed/35247012
http://dx.doi.org/10.1111/cas.15315

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