Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

BACKGROUND: Many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri has been used in China for over 2000 years to regulate liver-qi. Extracted from Radix Bupleuri, Saikosaponin D (SSD) is a ph...

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Detalles Bibliográficos
Autores principales: Liu, Chen-Yue, Chen, Jian-Bei, Liu, Yue-Yun, Zhou, Xue-Ming, Zhang, Man, Jiang, You-Ming, Ma, Qing-Yu, Xue, Zhe, Zhao, Zong-Yao, Li, Xiao-Juan, Chen, Jia-Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128259/
https://www.ncbi.nlm.nih.gov/pubmed/35610650
http://dx.doi.org/10.1186/s13020-022-00621-8

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