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Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors
The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. However, cellular immunity is essential for long-term viral control and protection from disease severity. To understand T-cell immunity in the absence of antibody generation we foc...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128381/ https://www.ncbi.nlm.nih.gov/pubmed/35619701 http://dx.doi.org/10.3389/fimmu.2022.815041 |
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author | Kilpeläinen, Athina Jimenez-Moyano, Esther Blanch-Lombarte, Oscar Ouchi, Dan Peña, Ruth Quirant-Sanchez, Bibiana Perez-Caballero, Raul Chamorro, Anna Blanco, Ignacio Martínez-Caceres, Eva Paredes, Roger Mateu, Lourdes Carrillo, Jorge Blanco, Julià Brander, Christian Massanella, Marta Clotet, Bonaventura Prado, Julia G. |
author_facet | Kilpeläinen, Athina Jimenez-Moyano, Esther Blanch-Lombarte, Oscar Ouchi, Dan Peña, Ruth Quirant-Sanchez, Bibiana Perez-Caballero, Raul Chamorro, Anna Blanco, Ignacio Martínez-Caceres, Eva Paredes, Roger Mateu, Lourdes Carrillo, Jorge Blanco, Julià Brander, Christian Massanella, Marta Clotet, Bonaventura Prado, Julia G. |
author_sort | Kilpeläinen, Athina |
collection | PubMed |
description | The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. However, cellular immunity is essential for long-term viral control and protection from disease severity. To understand T-cell immunity in the absence of antibody generation we focused on a group of SARS-CoV-2 Non-Seroconvertors (NSC) recovered from infection. We performed an immune comparative analysis of SARS-CoV-2 infected individuals stratified by the absence or presence of seroconversion and disease severity. We report high levels of total naïve and low effector CD8+ T cells in NSC. Moreover, reduced levels of T-cell activation monitored by PD-1 and activation-induced markers were observed in the context of functional SARS-CoV-2 T-cell responses. Longitudinal data indicate the stability of the NSC phenotype over three months of follow-up after infection. Together, these data characterized distinctive immunological traits in NSC including skewed cellular distribution, low activation and functional SARS-CoV-2 T-cell responses. This data highlights the value of T-cell immune monitoring in populations with low seroconversion rates in response to SARS-CoV-2 infection and vaccination. |
format | Online Article Text |
id | pubmed-9128381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91283812022-05-25 Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors Kilpeläinen, Athina Jimenez-Moyano, Esther Blanch-Lombarte, Oscar Ouchi, Dan Peña, Ruth Quirant-Sanchez, Bibiana Perez-Caballero, Raul Chamorro, Anna Blanco, Ignacio Martínez-Caceres, Eva Paredes, Roger Mateu, Lourdes Carrillo, Jorge Blanco, Julià Brander, Christian Massanella, Marta Clotet, Bonaventura Prado, Julia G. Front Immunol Immunology The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. However, cellular immunity is essential for long-term viral control and protection from disease severity. To understand T-cell immunity in the absence of antibody generation we focused on a group of SARS-CoV-2 Non-Seroconvertors (NSC) recovered from infection. We performed an immune comparative analysis of SARS-CoV-2 infected individuals stratified by the absence or presence of seroconversion and disease severity. We report high levels of total naïve and low effector CD8+ T cells in NSC. Moreover, reduced levels of T-cell activation monitored by PD-1 and activation-induced markers were observed in the context of functional SARS-CoV-2 T-cell responses. Longitudinal data indicate the stability of the NSC phenotype over three months of follow-up after infection. Together, these data characterized distinctive immunological traits in NSC including skewed cellular distribution, low activation and functional SARS-CoV-2 T-cell responses. This data highlights the value of T-cell immune monitoring in populations with low seroconversion rates in response to SARS-CoV-2 infection and vaccination. Frontiers Media S.A. 2022-05-10 /pmc/articles/PMC9128381/ /pubmed/35619701 http://dx.doi.org/10.3389/fimmu.2022.815041 Text en Copyright © 2022 Kilpeläinen, Jimenez-Moyano, Blanch-Lombarte, Ouchi, Peña, Quirant-Sanchez, Perez-Caballero, Chamorro, Blanco, Martínez-Caceres, Paredes, Mateu, Carrillo, Blanco, Brander, Massanella, Clotet and Prado https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kilpeläinen, Athina Jimenez-Moyano, Esther Blanch-Lombarte, Oscar Ouchi, Dan Peña, Ruth Quirant-Sanchez, Bibiana Perez-Caballero, Raul Chamorro, Anna Blanco, Ignacio Martínez-Caceres, Eva Paredes, Roger Mateu, Lourdes Carrillo, Jorge Blanco, Julià Brander, Christian Massanella, Marta Clotet, Bonaventura Prado, Julia G. Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors |
title | Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors |
title_full | Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors |
title_fullStr | Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors |
title_full_unstemmed | Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors |
title_short | Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors |
title_sort | skewed cellular distribution and low activation of functional t-cell responses in sars-cov-2 non-seroconvertors |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128381/ https://www.ncbi.nlm.nih.gov/pubmed/35619701 http://dx.doi.org/10.3389/fimmu.2022.815041 |
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