Differences and Limits of Agreement among Pentacam, Corvis-ST, and IOL-Master 700 Optical Biometric Devices regarding Central Corneal Thickness Measurements

PURPOSE: To investigate the differences and limits of agreement in measuring corneal thickness using Pentacam, Corvis, and intraocular lens (IOL)-Master 700 devices. METHODS: This study was conducted on 37 right eyes of 21 males and 16 females (n = 37) with a mean age of 52.11 ± 6.30 years. The central corneal thickness was measured using three optical biometric devices, including Pentacam, Corvis, and IOL-Master 700. The inclusion criteria were normal eyes without any ophthalmological abnormalities, history of ocular pathology, or ocular surgery. The data obtained from these three devices were compared two by two. The correlation and agreement limits among them were analyzed using statistical techniques. RESULTS: The mean standard deviation differences between Pentacam and Corvis, Pentacam and IOL-Master 700, as well as Corvis and IOL-Master 700 regarding the corneal thickness measurement, were 22.13 ± 8.05, 7.91 ± 8.02, and 14.21 ± 9.85 μm, respectively, which were statistically significant (P < 0.0001). Based on the investigation of the limits of agreement according to the Bland Altman method, the corresponding values between Pentacam and Corvis, Pentacam and IOL-Master 700, and Corvis and IOL-Master 700 were -16.2 to +15.4, -15.8 to +16.3, and -20.1 to +20.0 μm, respectively. Furthermore, the correlation coefficients of the measurements obtained by Pentacam and Corvis, Pentacam and IOL-Master 700, as well as Corvis and IOL-Master 700 were determined 0.957, 0.964, and 0.948, respectively (P < 0.0001). CONCLUSION: The results from this study indicate that the interchangeable use of these three devices is not appropriate due to statistically significant differences and broad limits of agreement among the three devices, especially between Corvis and IOL-Master 700.