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Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center

INTRODUCTION: Epilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the continental size of country. OBJECTIVE: We aimed to present the first evidence...

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Autores principales: Buainain, Renata Parissi, Oliveira, Carlos Tadeu Parisi, Marson, Fernando Augusto Lima, Ortega, Manoela Marques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128524/
https://www.ncbi.nlm.nih.gov/pubmed/35620790
http://dx.doi.org/10.3389/fneur.2022.822537
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author Buainain, Renata Parissi
Oliveira, Carlos Tadeu Parisi
Marson, Fernando Augusto Lima
Ortega, Manoela Marques
author_facet Buainain, Renata Parissi
Oliveira, Carlos Tadeu Parisi
Marson, Fernando Augusto Lima
Ortega, Manoela Marques
author_sort Buainain, Renata Parissi
collection PubMed
description INTRODUCTION: Epilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the continental size of country. OBJECTIVE: We aimed to present the first evidence-based study on the epidemiological aspects of individuals with epilepsy, mapping the characteristics of this disease in a referral center in a region of Southeast Brazil. METHODS: A retrospective study was carried out from January 2010 to March 2021. Patients were selected according to the International League Against Epilepsy Criteria. RESULTS: From a total of 618 selected patients, 317 (51.3%) were men and 301 (48.7%) were women with an average age of 34.03 ± 20.66 years. The average age at the first seizure was 15.16 ± 17.61 years. The prevalence ratio was 1.30 cases/1,000 habitants. Childhood febrile seizure was present in 44 patients (7.9%) and family history of epilepsy in 231 (37.4%) patients. The predominant type of seizure was focal in 401 (64.9%) patients. The most frequent etiologies were structural in 254 (41.1%) patients and unknown in 238 (38.5%) patients. Most of the patients' treatments were based on anti-seizure drugs in monotherapy [389 (62.9%)] with 398 (64.4%) drug-responsive patients. CONCLUSIONS: Our epilepsy prevalence rate was lower than other studies in the Southeast Region of Brazil. In addition, the structural epilepsy type was predominant in our study compared with unknown causes, which is more frequent in other Brazilian regions and worldwide studies. The differences may be attributed to our region, which presents a high prevalence of neuroinfection, specially neurocysticercosis, and a referral center for traumatic brain injury. Moreover, the contrasting results reinforce the need for an adequate epidemiological assessment of epilepsy incidence in a region of Southeast Brazil.
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spelling pubmed-91285242022-05-25 Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center Buainain, Renata Parissi Oliveira, Carlos Tadeu Parisi Marson, Fernando Augusto Lima Ortega, Manoela Marques Front Neurol Neurology INTRODUCTION: Epilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the continental size of country. OBJECTIVE: We aimed to present the first evidence-based study on the epidemiological aspects of individuals with epilepsy, mapping the characteristics of this disease in a referral center in a region of Southeast Brazil. METHODS: A retrospective study was carried out from January 2010 to March 2021. Patients were selected according to the International League Against Epilepsy Criteria. RESULTS: From a total of 618 selected patients, 317 (51.3%) were men and 301 (48.7%) were women with an average age of 34.03 ± 20.66 years. The average age at the first seizure was 15.16 ± 17.61 years. The prevalence ratio was 1.30 cases/1,000 habitants. Childhood febrile seizure was present in 44 patients (7.9%) and family history of epilepsy in 231 (37.4%) patients. The predominant type of seizure was focal in 401 (64.9%) patients. The most frequent etiologies were structural in 254 (41.1%) patients and unknown in 238 (38.5%) patients. Most of the patients' treatments were based on anti-seizure drugs in monotherapy [389 (62.9%)] with 398 (64.4%) drug-responsive patients. CONCLUSIONS: Our epilepsy prevalence rate was lower than other studies in the Southeast Region of Brazil. In addition, the structural epilepsy type was predominant in our study compared with unknown causes, which is more frequent in other Brazilian regions and worldwide studies. The differences may be attributed to our region, which presents a high prevalence of neuroinfection, specially neurocysticercosis, and a referral center for traumatic brain injury. Moreover, the contrasting results reinforce the need for an adequate epidemiological assessment of epilepsy incidence in a region of Southeast Brazil. Frontiers Media S.A. 2022-05-10 /pmc/articles/PMC9128524/ /pubmed/35620790 http://dx.doi.org/10.3389/fneur.2022.822537 Text en Copyright © 2022 Buainain, Oliveira, Marson and Ortega. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Buainain, Renata Parissi
Oliveira, Carlos Tadeu Parisi
Marson, Fernando Augusto Lima
Ortega, Manoela Marques
Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
title Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
title_full Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
title_fullStr Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
title_full_unstemmed Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
title_short Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
title_sort epidemiologic profile of patients with epilepsy in a region of southeast brazil: data from a referral center
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128524/
https://www.ncbi.nlm.nih.gov/pubmed/35620790
http://dx.doi.org/10.3389/fneur.2022.822537
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