SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression

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Major histocompatibility complex class I (MHC-I) molecules, which are dimers of a glycosylated polymorphic transmembrane heavy chain and the small protein β(2)-microglobulin (β(2)m), bind peptides in the endoplasmic reticulum that are generated by the cytosolic turnover of cellular proteins. In viru...

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Detalles Bibliográficos
Autores principales: Arshad, Najla, Laurent-Rolle, Maudry, Ahmed, Wesam S, Hsu, Jack Chun-Chieh, Mitchell, Susan M, Pawlak, Joanna, Sengupta, Debrup, Biswas, Kabir H, Cresswell, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128780/
https://www.ncbi.nlm.nih.gov/pubmed/35611331
http://dx.doi.org/10.1101/2022.05.17.492198

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