Cargando…

Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study

Prurigo nodularis is a pruritic dermatosis with poor treatment options. To describe treatment patterns, comorbidities, pruritus, and quality of life a survey was administered to 92 patients with prurigo nodularis. A total of 52 patients completed the survey. The most frequently used treatments were...

Descripción completa

Detalles Bibliográficos
Autores principales: TODBERG, Tanja, ZACHARIAE, Claus, SKOV, Lone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128953/
https://www.ncbi.nlm.nih.gov/pubmed/32215661
http://dx.doi.org/10.2340/00015555-3471
_version_ 1784712655645179904
author TODBERG, Tanja
ZACHARIAE, Claus
SKOV, Lone
author_facet TODBERG, Tanja
ZACHARIAE, Claus
SKOV, Lone
author_sort TODBERG, Tanja
collection PubMed
description Prurigo nodularis is a pruritic dermatosis with poor treatment options. To describe treatment patterns, comorbidities, pruritus, and quality of life a survey was administered to 92 patients with prurigo nodularis. A total of 52 patients completed the survey. The most frequently used treatments were topical corticosteroids, which were prescribed to 49/52 patients, with positive effect in 13/49. A total of 46/52 patients were treated with ultraviolet B, and 9/46 reported a positive effect. A positive effect was reported for topical corticosteroids under occlusion in 21/40, for zinc dressing treatment in 17/37, for steroid injection in 9/14, for methotrexate in 5/16, and for thalidomide in 4/12 of treated patients. Thirty-six patients reported a Pittsburgh Sleep Quality Index >5, indicating poor sleep. Patients with prurigo nodularis are severely bothered by pruritus negatively affecting quality of life. Various treatments are prescribed; most frequently topical corticosteroids and ultraviolet B. Surprisingly, patients reported topical corticosteroids under occlusion, zinc-dressing treatment and steroid injection as the most effective.
format Online
Article
Text
id pubmed-9128953
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Society for Publication of Acta Dermato-Venereologica
record_format MEDLINE/PubMed
spelling pubmed-91289532022-10-20 Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study TODBERG, Tanja ZACHARIAE, Claus SKOV, Lone Acta Derm Venereol Clinical Report Prurigo nodularis is a pruritic dermatosis with poor treatment options. To describe treatment patterns, comorbidities, pruritus, and quality of life a survey was administered to 92 patients with prurigo nodularis. A total of 52 patients completed the survey. The most frequently used treatments were topical corticosteroids, which were prescribed to 49/52 patients, with positive effect in 13/49. A total of 46/52 patients were treated with ultraviolet B, and 9/46 reported a positive effect. A positive effect was reported for topical corticosteroids under occlusion in 21/40, for zinc dressing treatment in 17/37, for steroid injection in 9/14, for methotrexate in 5/16, and for thalidomide in 4/12 of treated patients. Thirty-six patients reported a Pittsburgh Sleep Quality Index >5, indicating poor sleep. Patients with prurigo nodularis are severely bothered by pruritus negatively affecting quality of life. Various treatments are prescribed; most frequently topical corticosteroids and ultraviolet B. Surprisingly, patients reported topical corticosteroids under occlusion, zinc-dressing treatment and steroid injection as the most effective. Society for Publication of Acta Dermato-Venereologica 2020-04-21 /pmc/articles/PMC9128953/ /pubmed/32215661 http://dx.doi.org/10.2340/00015555-3471 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Clinical Report
TODBERG, Tanja
ZACHARIAE, Claus
SKOV, Lone
Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
title Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
title_full Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
title_fullStr Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
title_full_unstemmed Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
title_short Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
title_sort treatment and burden of disease in a cohort of patients with prurigo nodularis: a survey-based study
topic Clinical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128953/
https://www.ncbi.nlm.nih.gov/pubmed/32215661
http://dx.doi.org/10.2340/00015555-3471
work_keys_str_mv AT todbergtanja treatmentandburdenofdiseaseinacohortofpatientswithprurigonodularisasurveybasedstudy
AT zachariaeclaus treatmentandburdenofdiseaseinacohortofpatientswithprurigonodularisasurveybasedstudy
AT skovlone treatmentandburdenofdiseaseinacohortofpatientswithprurigonodularisasurveybasedstudy