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Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Publication of Acta Dermato-Venereologica
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128964/ https://www.ncbi.nlm.nih.gov/pubmed/31742649 http://dx.doi.org/10.2340/00015555-3375 |
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author | KLEYN, C. Elise TALBOT, Peter S. MEHTA, Nehal N. SAMPOGNA, Francesca BUNDY, Chris ASHCROFT, Darren M. KIMBALL, Alexa B. VAN DE KERKHOF, Peter GRIFFITHS, Christopher E. M. VALENZUELA, Fernando VAN DER WALT, Joelle M. ABERRA, Tsion PUIG, Lluís |
author_facet | KLEYN, C. Elise TALBOT, Peter S. MEHTA, Nehal N. SAMPOGNA, Francesca BUNDY, Chris ASHCROFT, Darren M. KIMBALL, Alexa B. VAN DE KERKHOF, Peter GRIFFITHS, Christopher E. M. VALENZUELA, Fernando VAN DER WALT, Joelle M. ABERRA, Tsion PUIG, Lluís |
author_sort | KLEYN, C. Elise |
collection | PubMed |
description | Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention. |
format | Online Article Text |
id | pubmed-9128964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-91289642022-10-20 Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk KLEYN, C. Elise TALBOT, Peter S. MEHTA, Nehal N. SAMPOGNA, Francesca BUNDY, Chris ASHCROFT, Darren M. KIMBALL, Alexa B. VAN DE KERKHOF, Peter GRIFFITHS, Christopher E. M. VALENZUELA, Fernando VAN DER WALT, Joelle M. ABERRA, Tsion PUIG, Lluís Acta Derm Venereol Review Article Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention. Society for Publication of Acta Dermato-Venereologica 2020-01-07 /pmc/articles/PMC9128964/ /pubmed/31742649 http://dx.doi.org/10.2340/00015555-3375 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Review Article KLEYN, C. Elise TALBOT, Peter S. MEHTA, Nehal N. SAMPOGNA, Francesca BUNDY, Chris ASHCROFT, Darren M. KIMBALL, Alexa B. VAN DE KERKHOF, Peter GRIFFITHS, Christopher E. M. VALENZUELA, Fernando VAN DER WALT, Joelle M. ABERRA, Tsion PUIG, Lluís Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title | Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_full | Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_fullStr | Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_full_unstemmed | Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_short | Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_sort | psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128964/ https://www.ncbi.nlm.nih.gov/pubmed/31742649 http://dx.doi.org/10.2340/00015555-3375 |
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