Cargando…

Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk

Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains...

Descripción completa

Detalles Bibliográficos
Autores principales: KLEYN, C. Elise, TALBOT, Peter S., MEHTA, Nehal N., SAMPOGNA, Francesca, BUNDY, Chris, ASHCROFT, Darren M., KIMBALL, Alexa B., VAN DE KERKHOF, Peter, GRIFFITHS, Christopher E. M., VALENZUELA, Fernando, VAN DER WALT, Joelle M., ABERRA, Tsion, PUIG, Lluís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128964/
https://www.ncbi.nlm.nih.gov/pubmed/31742649
http://dx.doi.org/10.2340/00015555-3375
_version_ 1784712658271862784
author KLEYN, C. Elise
TALBOT, Peter S.
MEHTA, Nehal N.
SAMPOGNA, Francesca
BUNDY, Chris
ASHCROFT, Darren M.
KIMBALL, Alexa B.
VAN DE KERKHOF, Peter
GRIFFITHS, Christopher E. M.
VALENZUELA, Fernando
VAN DER WALT, Joelle M.
ABERRA, Tsion
PUIG, Lluís
author_facet KLEYN, C. Elise
TALBOT, Peter S.
MEHTA, Nehal N.
SAMPOGNA, Francesca
BUNDY, Chris
ASHCROFT, Darren M.
KIMBALL, Alexa B.
VAN DE KERKHOF, Peter
GRIFFITHS, Christopher E. M.
VALENZUELA, Fernando
VAN DER WALT, Joelle M.
ABERRA, Tsion
PUIG, Lluís
author_sort KLEYN, C. Elise
collection PubMed
description Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention.
format Online
Article
Text
id pubmed-9128964
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Society for Publication of Acta Dermato-Venereologica
record_format MEDLINE/PubMed
spelling pubmed-91289642022-10-20 Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk KLEYN, C. Elise TALBOT, Peter S. MEHTA, Nehal N. SAMPOGNA, Francesca BUNDY, Chris ASHCROFT, Darren M. KIMBALL, Alexa B. VAN DE KERKHOF, Peter GRIFFITHS, Christopher E. M. VALENZUELA, Fernando VAN DER WALT, Joelle M. ABERRA, Tsion PUIG, Lluís Acta Derm Venereol Review Article Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention. Society for Publication of Acta Dermato-Venereologica 2020-01-07 /pmc/articles/PMC9128964/ /pubmed/31742649 http://dx.doi.org/10.2340/00015555-3375 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Review Article
KLEYN, C. Elise
TALBOT, Peter S.
MEHTA, Nehal N.
SAMPOGNA, Francesca
BUNDY, Chris
ASHCROFT, Darren M.
KIMBALL, Alexa B.
VAN DE KERKHOF, Peter
GRIFFITHS, Christopher E. M.
VALENZUELA, Fernando
VAN DER WALT, Joelle M.
ABERRA, Tsion
PUIG, Lluís
Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
title Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
title_full Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
title_fullStr Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
title_full_unstemmed Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
title_short Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
title_sort psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128964/
https://www.ncbi.nlm.nih.gov/pubmed/31742649
http://dx.doi.org/10.2340/00015555-3375
work_keys_str_mv AT kleyncelise psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT talbotpeters psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT mehtanehaln psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT sampognafrancesca psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT bundychris psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT ashcroftdarrenm psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT kimballalexab psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT vandekerkhofpeter psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT griffithschristopherem psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT valenzuelafernando psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT vanderwaltjoellem psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT aberratsion psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk
AT puiglluis psoriasisandmentalhealthworkshopreportexploringthelinksbetweenpsychosocialfactorspsoriasisneuroinflammationandcardiovasculardiseaserisk