Cargando…
Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis
Atopic dermatitis (AD) is a common chronic, inflammatory skin disorder associated with Staphylococcus aureus colonization and reduced microbiota diversity (1–3). New treatments are being evaluated using clinical AD scores and skin microbiota composition (4–8). Most study designs include the collecti...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society for Publication of Acta Dermato-Venereologica
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128996/ https://www.ncbi.nlm.nih.gov/pubmed/31742645 http://dx.doi.org/10.2340/00015555-3373 |
| _version_ | 1784712666282983424 |
|---|---|
| author | VAN DEN MUNCKHOF, Ellen H. A. NIEMEYER-VAN DER KOLK, Tessa VAN DER WALL, Hein VAN ALEWIJK, Dirk C. J. G. VAN DOORN, Martijn B. A. BURGGRAAF, Jacobus BUTERS, Thomas P. BECKER, Martin J. FEISS, Gary L. QUINT, Wim G. V. VAN DOORN, Leen-Jan KNETSCH, Cornelis W. RISSMANN, Robert |
| author_facet | VAN DEN MUNCKHOF, Ellen H. A. NIEMEYER-VAN DER KOLK, Tessa VAN DER WALL, Hein VAN ALEWIJK, Dirk C. J. G. VAN DOORN, Martijn B. A. BURGGRAAF, Jacobus BUTERS, Thomas P. BECKER, Martin J. FEISS, Gary L. QUINT, Wim G. V. VAN DOORN, Leen-Jan KNETSCH, Cornelis W. RISSMANN, Robert |
| author_sort | VAN DEN MUNCKHOF, Ellen H. A. |
| collection | PubMed |
| description | Atopic dermatitis (AD) is a common chronic, inflammatory skin disorder associated with Staphylococcus aureus colonization and reduced microbiota diversity (1–3). New treatments are being evaluated using clinical AD scores and skin microbiota composition (4–8). Most study designs include the collection of a single sample before and after treatment. The aim of the current evaluation was to analyse inter- and intra-patient variability of the skin microbiota of patients with AD over time to determine whether limited sampling is sufficient to capture the full extent of variability in the skin microbiota. |
| format | Online Article Text |
| id | pubmed-9128996 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Society for Publication of Acta Dermato-Venereologica |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91289962022-10-20 Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis VAN DEN MUNCKHOF, Ellen H. A. NIEMEYER-VAN DER KOLK, Tessa VAN DER WALL, Hein VAN ALEWIJK, Dirk C. J. G. VAN DOORN, Martijn B. A. BURGGRAAF, Jacobus BUTERS, Thomas P. BECKER, Martin J. FEISS, Gary L. QUINT, Wim G. V. VAN DOORN, Leen-Jan KNETSCH, Cornelis W. RISSMANN, Robert Acta Derm Venereol Short Communication Atopic dermatitis (AD) is a common chronic, inflammatory skin disorder associated with Staphylococcus aureus colonization and reduced microbiota diversity (1–3). New treatments are being evaluated using clinical AD scores and skin microbiota composition (4–8). Most study designs include the collection of a single sample before and after treatment. The aim of the current evaluation was to analyse inter- and intra-patient variability of the skin microbiota of patients with AD over time to determine whether limited sampling is sufficient to capture the full extent of variability in the skin microbiota. Society for Publication of Acta Dermato-Venereologica 2020-01-07 /pmc/articles/PMC9128996/ /pubmed/31742645 http://dx.doi.org/10.2340/00015555-3373 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
| spellingShingle | Short Communication VAN DEN MUNCKHOF, Ellen H. A. NIEMEYER-VAN DER KOLK, Tessa VAN DER WALL, Hein VAN ALEWIJK, Dirk C. J. G. VAN DOORN, Martijn B. A. BURGGRAAF, Jacobus BUTERS, Thomas P. BECKER, Martin J. FEISS, Gary L. QUINT, Wim G. V. VAN DOORN, Leen-Jan KNETSCH, Cornelis W. RISSMANN, Robert Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis |
| title | Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis |
| title_full | Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis |
| title_fullStr | Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis |
| title_full_unstemmed | Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis |
| title_short | Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis |
| title_sort | inter- and intra-patient variability over time of lesional skin microbiota in adult patients with atopic dermatitis |
| topic | Short Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128996/ https://www.ncbi.nlm.nih.gov/pubmed/31742645 http://dx.doi.org/10.2340/00015555-3373 |
| work_keys_str_mv | AT vandenmunckhofellenha interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT niemeyervanderkolktessa interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT vanderwallhein interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT vanalewijkdirkcjg interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT vandoornmartijnba interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT burggraafjacobus interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT butersthomasp interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT beckermartinj interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT feissgaryl interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT quintwimgv interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT vandoornleenjan interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT knetschcornelisw interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis AT rissmannrobert interandintrapatientvariabilityovertimeoflesionalskinmicrobiotainadultpatientswithatopicdermatitis |