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No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an in...

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Autores principales: Lu-Culligan, Alice, Tabachnikova, Alexandra, Pérez-Then, Eddy, Tokuyama, Maria, Lee, Hannah J., Lucas, Carolina, Silva Monteiro, Valter, Miric, Marija, Brache, Vivian, Cochon, Leila, Muenker, M. Catherine, Mohanty, Subhasis, Huang, Jiefang, Kang, Insoo, Dela Cruz, Charles, Farhadian, Shelli, Campbell, Melissa, Yildirim, Inci, Shaw, Albert C., Ma, Shuangge, Vermund, Sten H., Ko, Albert I., Omer, Saad B., Iwasaki, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129011/
https://www.ncbi.nlm.nih.gov/pubmed/35609110
http://dx.doi.org/10.1371/journal.pbio.3001506
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author Lu-Culligan, Alice
Tabachnikova, Alexandra
Pérez-Then, Eddy
Tokuyama, Maria
Lee, Hannah J.
Lucas, Carolina
Silva Monteiro, Valter
Miric, Marija
Brache, Vivian
Cochon, Leila
Muenker, M. Catherine
Mohanty, Subhasis
Huang, Jiefang
Kang, Insoo
Dela Cruz, Charles
Farhadian, Shelli
Campbell, Melissa
Yildirim, Inci
Shaw, Albert C.
Ma, Shuangge
Vermund, Sten H.
Ko, Albert I.
Omer, Saad B.
Iwasaki, Akiko
author_facet Lu-Culligan, Alice
Tabachnikova, Alexandra
Pérez-Then, Eddy
Tokuyama, Maria
Lee, Hannah J.
Lucas, Carolina
Silva Monteiro, Valter
Miric, Marija
Brache, Vivian
Cochon, Leila
Muenker, M. Catherine
Mohanty, Subhasis
Huang, Jiefang
Kang, Insoo
Dela Cruz, Charles
Farhadian, Shelli
Campbell, Melissa
Yildirim, Inci
Shaw, Albert C.
Ma, Shuangge
Vermund, Sten H.
Ko, Albert I.
Omer, Saad B.
Iwasaki, Akiko
author_sort Lu-Culligan, Alice
collection PubMed
description The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7.5 did not lead to differences in fetal size by crown-rump length or weight at term, nor did we observe any gross birth defects. In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size. No overt maternal illness following either vaccination or poly(I:C) exposure was observed. We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. Finally, we did not detect increased levels of circulating anti-syncytin-1 antibodies in a cohort of COVID-19 vaccinated adults compared to unvaccinated adults by ELISA. Our findings contradict popular claims associating COVID-19 mRNA vaccination with infertility and adverse neonatal outcomes.
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spelling pubmed-91290112022-05-25 No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination Lu-Culligan, Alice Tabachnikova, Alexandra Pérez-Then, Eddy Tokuyama, Maria Lee, Hannah J. Lucas, Carolina Silva Monteiro, Valter Miric, Marija Brache, Vivian Cochon, Leila Muenker, M. Catherine Mohanty, Subhasis Huang, Jiefang Kang, Insoo Dela Cruz, Charles Farhadian, Shelli Campbell, Melissa Yildirim, Inci Shaw, Albert C. Ma, Shuangge Vermund, Sten H. Ko, Albert I. Omer, Saad B. Iwasaki, Akiko PLoS Biol Short Reports The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7.5 did not lead to differences in fetal size by crown-rump length or weight at term, nor did we observe any gross birth defects. In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size. No overt maternal illness following either vaccination or poly(I:C) exposure was observed. We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. Finally, we did not detect increased levels of circulating anti-syncytin-1 antibodies in a cohort of COVID-19 vaccinated adults compared to unvaccinated adults by ELISA. Our findings contradict popular claims associating COVID-19 mRNA vaccination with infertility and adverse neonatal outcomes. Public Library of Science 2022-05-24 /pmc/articles/PMC9129011/ /pubmed/35609110 http://dx.doi.org/10.1371/journal.pbio.3001506 Text en © 2022 Lu-Culligan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Short Reports
Lu-Culligan, Alice
Tabachnikova, Alexandra
Pérez-Then, Eddy
Tokuyama, Maria
Lee, Hannah J.
Lucas, Carolina
Silva Monteiro, Valter
Miric, Marija
Brache, Vivian
Cochon, Leila
Muenker, M. Catherine
Mohanty, Subhasis
Huang, Jiefang
Kang, Insoo
Dela Cruz, Charles
Farhadian, Shelli
Campbell, Melissa
Yildirim, Inci
Shaw, Albert C.
Ma, Shuangge
Vermund, Sten H.
Ko, Albert I.
Omer, Saad B.
Iwasaki, Akiko
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
title No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
title_full No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
title_fullStr No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
title_full_unstemmed No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
title_short No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
title_sort no evidence of fetal defects or anti-syncytin-1 antibody induction following covid-19 mrna vaccination
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129011/
https://www.ncbi.nlm.nih.gov/pubmed/35609110
http://dx.doi.org/10.1371/journal.pbio.3001506
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