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No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an in...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129011/ https://www.ncbi.nlm.nih.gov/pubmed/35609110 http://dx.doi.org/10.1371/journal.pbio.3001506 |
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author | Lu-Culligan, Alice Tabachnikova, Alexandra Pérez-Then, Eddy Tokuyama, Maria Lee, Hannah J. Lucas, Carolina Silva Monteiro, Valter Miric, Marija Brache, Vivian Cochon, Leila Muenker, M. Catherine Mohanty, Subhasis Huang, Jiefang Kang, Insoo Dela Cruz, Charles Farhadian, Shelli Campbell, Melissa Yildirim, Inci Shaw, Albert C. Ma, Shuangge Vermund, Sten H. Ko, Albert I. Omer, Saad B. Iwasaki, Akiko |
author_facet | Lu-Culligan, Alice Tabachnikova, Alexandra Pérez-Then, Eddy Tokuyama, Maria Lee, Hannah J. Lucas, Carolina Silva Monteiro, Valter Miric, Marija Brache, Vivian Cochon, Leila Muenker, M. Catherine Mohanty, Subhasis Huang, Jiefang Kang, Insoo Dela Cruz, Charles Farhadian, Shelli Campbell, Melissa Yildirim, Inci Shaw, Albert C. Ma, Shuangge Vermund, Sten H. Ko, Albert I. Omer, Saad B. Iwasaki, Akiko |
author_sort | Lu-Culligan, Alice |
collection | PubMed |
description | The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7.5 did not lead to differences in fetal size by crown-rump length or weight at term, nor did we observe any gross birth defects. In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size. No overt maternal illness following either vaccination or poly(I:C) exposure was observed. We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. Finally, we did not detect increased levels of circulating anti-syncytin-1 antibodies in a cohort of COVID-19 vaccinated adults compared to unvaccinated adults by ELISA. Our findings contradict popular claims associating COVID-19 mRNA vaccination with infertility and adverse neonatal outcomes. |
format | Online Article Text |
id | pubmed-9129011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91290112022-05-25 No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination Lu-Culligan, Alice Tabachnikova, Alexandra Pérez-Then, Eddy Tokuyama, Maria Lee, Hannah J. Lucas, Carolina Silva Monteiro, Valter Miric, Marija Brache, Vivian Cochon, Leila Muenker, M. Catherine Mohanty, Subhasis Huang, Jiefang Kang, Insoo Dela Cruz, Charles Farhadian, Shelli Campbell, Melissa Yildirim, Inci Shaw, Albert C. Ma, Shuangge Vermund, Sten H. Ko, Albert I. Omer, Saad B. Iwasaki, Akiko PLoS Biol Short Reports The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7.5 did not lead to differences in fetal size by crown-rump length or weight at term, nor did we observe any gross birth defects. In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size. No overt maternal illness following either vaccination or poly(I:C) exposure was observed. We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. Finally, we did not detect increased levels of circulating anti-syncytin-1 antibodies in a cohort of COVID-19 vaccinated adults compared to unvaccinated adults by ELISA. Our findings contradict popular claims associating COVID-19 mRNA vaccination with infertility and adverse neonatal outcomes. Public Library of Science 2022-05-24 /pmc/articles/PMC9129011/ /pubmed/35609110 http://dx.doi.org/10.1371/journal.pbio.3001506 Text en © 2022 Lu-Culligan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Short Reports Lu-Culligan, Alice Tabachnikova, Alexandra Pérez-Then, Eddy Tokuyama, Maria Lee, Hannah J. Lucas, Carolina Silva Monteiro, Valter Miric, Marija Brache, Vivian Cochon, Leila Muenker, M. Catherine Mohanty, Subhasis Huang, Jiefang Kang, Insoo Dela Cruz, Charles Farhadian, Shelli Campbell, Melissa Yildirim, Inci Shaw, Albert C. Ma, Shuangge Vermund, Sten H. Ko, Albert I. Omer, Saad B. Iwasaki, Akiko No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination |
title | No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination |
title_full | No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination |
title_fullStr | No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination |
title_full_unstemmed | No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination |
title_short | No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination |
title_sort | no evidence of fetal defects or anti-syncytin-1 antibody induction following covid-19 mrna vaccination |
topic | Short Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129011/ https://www.ncbi.nlm.nih.gov/pubmed/35609110 http://dx.doi.org/10.1371/journal.pbio.3001506 |
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