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Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma

Our previous study demonstrated that guaiane-type sesquiterpenoid ludartin showed potent antihepatoma activity against two human hepatocellular carcinoma cell lines, HepG2 and Huh7, with IC(50) values of 32.7 and 34.3 μM, respectively. In this study, 34 ludartin derivatives were designed, synthesize...

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Detalles Bibliográficos
Autores principales:	Sun, Jin-Jin, Wang, Jin-Ping, Li, Tian-Ze, Ma, Yun-Bao, Xue, Dong, Chen, Ji-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129064/ https://www.ncbi.nlm.nih.gov/pubmed/35634434 http://dx.doi.org/10.1007/s00044-022-02890-2

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