Insulin resistance in first episode antipsychotic naïve psychosis patients-A cross sectional study.

BACKGROUND :-: Patients with psychosis experiencing premature mortality in comparison with general population is now established with evidences. Insulin resistance is a fundamental aspect of causes of type 2 diabetes. Most of the second generation antipsychotics lead to substantial weight gain which is a major risk factor for diabetes and coronary heart disease. In this study, we assessed insulin resistance in first episode psychosis patients to know whether the insulin derangement occurs independent of the use of antipsychotics. AIMS AND OBJECTIVES:-: • To measure insulin resistance in cases of antipsychotic naïve first episode psychosis and to compare with healthy controls. METHODS:-: A cross sectional study was conducted to assess the insulin resistance among antipsychotic naïve first episode psychosis patients attending KIMS Psychiatry OPD. Thirty patients fulfilling inclusion criteria and thirty healthy individuals were taken as cases and controls respectively by convenience sampling. Semi-structured proforma was applied after taking written consent and diagnosis was made using using ICD-10. Insulin resistance was measured using HOMA IR formula. Statistical analysis was done using SPSS version 22 and Chi-square test was done and p value of <0.05 was considered as significant. RESULTS:-: Mean age was 33.90 and 36.63 years among cases and control group respectively. Insulin resistance was statistically significant in cases of psychosis patients in comparison to healthy controls with the p value of 0.044. CONCLUSION:-: Patients with psychosis are possibly at risk to develop insulin resistance, hence it is rational to screen for risk of diabetes before choosing antipsychotics in all patients with psychosis.