Abstract for Free Paper-ANCIPS 2022 Case report of olanzapine induced psoriasis in a young adult male with Acute Transient Psychotic Disorder

Olanzapine is an efficacious commonly used second generation anti-psychotic. Metabolic side effects of olanzapine are well known. Skin rash which may range from benign erythematous rash to severe hypersensitivity reaction is a lesser known complication. Here is a case of a 26 year old patient with no known co-morbidities or drug allergies who was diagnosed to have Acute Transient Psychotic Disorder. He was started on olanzapine 5 mg and dose increased up to 10 mg. Within 72 hours patient developed psoriatic rash (which was confirmed by biopsy) over his face and upper limbs. He had no past of family history of psoriasis. Change of anti-psychotic and topical treatment for psoriasis was started and the patient recovered. Olanzapine re-challenge was not attempted due to severity of the reaction and presence of safer alternatives. Conclusion: Olanzapine induced drug rash can be a serious side effect that clinicians should be aware of and vigilant as it can be severe enough to be life threatening.