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Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K(+) channel TMEM175

Structures of the human lysosomal K(+) channel transmembrane protein 175 (TMEM175) in open and closed states revealed a novel architecture lacking the canonical K(+) selectivity filter motif present in previously known K(+) channel structures. A hydrophobic constriction composed of four isoleucine r...

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Detalles Bibliográficos
Autores principales:	Oh, SeCheol, Marinelli, Fabrizio, Zhou, Wenchang, Lee, Jooyeon, Choi, Ho Jeong, Kim, Min, Faraldo-Gómez, José D, Hite, Richard K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129878/ https://www.ncbi.nlm.nih.gov/pubmed/35608336 http://dx.doi.org/10.7554/eLife.75122

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