Transcriptomic perspectives of memory-like NK cells and aging

A recent study highlights the presence of a unique memory-like natural killer (NK) cell subset, which accumulates with aging and appears to associate withdisease severity in COVID-19 patients. While the clinical relevance of memory in NK cells is being debated, the molecular identity of this subset...

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Autores principales: Wang, Dandan, Malarkannan, Subramaniam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129893/
https://www.ncbi.nlm.nih.gov/pubmed/35610660
http://dx.doi.org/10.1186/s13073-022-01059-1
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author Wang, Dandan
Malarkannan, Subramaniam
author_facet Wang, Dandan
Malarkannan, Subramaniam
author_sort Wang, Dandan
collection PubMed
description A recent study highlights the presence of a unique memory-like natural killer (NK) cell subset, which accumulates with aging and appears to associate withdisease severity in COVID-19 patients. While the clinical relevance of memory in NK cells is being debated, the molecular identity of this subset in the form of a single-cell transcriptome is essential to define their origin, longevity, functions, and disease relevance.
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spelling pubmed-91298932022-05-25 Transcriptomic perspectives of memory-like NK cells and aging Wang, Dandan Malarkannan, Subramaniam Genome Med Research Highlight A recent study highlights the presence of a unique memory-like natural killer (NK) cell subset, which accumulates with aging and appears to associate withdisease severity in COVID-19 patients. While the clinical relevance of memory in NK cells is being debated, the molecular identity of this subset in the form of a single-cell transcriptome is essential to define their origin, longevity, functions, and disease relevance. BioMed Central 2022-05-25 /pmc/articles/PMC9129893/ /pubmed/35610660 http://dx.doi.org/10.1186/s13073-022-01059-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Highlight
Wang, Dandan
Malarkannan, Subramaniam
Transcriptomic perspectives of memory-like NK cells and aging
title Transcriptomic perspectives of memory-like NK cells and aging
title_full Transcriptomic perspectives of memory-like NK cells and aging
title_fullStr Transcriptomic perspectives of memory-like NK cells and aging
title_full_unstemmed Transcriptomic perspectives of memory-like NK cells and aging
title_short Transcriptomic perspectives of memory-like NK cells and aging
title_sort transcriptomic perspectives of memory-like nk cells and aging
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129893/
https://www.ncbi.nlm.nih.gov/pubmed/35610660
http://dx.doi.org/10.1186/s13073-022-01059-1
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