A Hybrid Approach for MS Diagnosis Through Nonlinear EEG Descriptors and Metaheuristic Optimized Classification Learning

Multiple sclerosis (MS), a disease of the central nervous system, affects the white matter of the brain. Neurologists interpret magnetic resonance images that are often complicated, time-consuming, and contradictory. Using EEG signals, this disease can be analyzed and diagnosed more accurately. However, it is imperative that MS be diagnosed by specialists using assistive technology. Until now, a few methods have been proposed in this field that are sometimes associated with different challenges in analysis. This paper presents a hybrid approach to MS diagnosis in order to decrease classification error rates. Using the proposed method, EEG descriptors in both the time and frequency domains are analyzed. After the feature extraction stage, a modified version of the ant colony optimization method (m-ACO) was used to select the appropriate subset of features. Then, the support vector machine is used to determine whether the disease exists. A metaheuristic algorithm adjusts the support vector machine's parameters to withstand overfitting challenges. Despite a limited number of input channels, significant classification accuracy has been achieved using wavelet analysis techniques, dividing all five subbands of EEG signals, signal windowing, and extracting efficient features from the data. Additionally, alpha, beta, and gamma bands of the signal are important, and the accuracy, sensitivity, and specificity levels are higher than 98.5%. Compared to similar MS diagnostic methods, the proposed method achieved significantly higher diagnostic accuracy. Application and implementation of this method can be effective in treating neurological diseases, including multiple sclerosis.