Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf--lammasome Activation, and Reversing Gut Microbiota Disorder

Radiation-induced intestinal injury is a common and critical complication of radiotherapy for pelvic or abdominal tumors, with limited therapeutic strategies and effectiveness. Sitagliptin, a dipeptidyl peptidase IV (DPP4) inhibitor, has previously been reported to alleviate total body irradiation-...

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Detalles Bibliográficos
Autores principales: Huang, Shanshan, Huang, Yongbiao, Lin, Wanling, Wang, Lei, Yang, Yang, Li, Piao, Xiao, Lei, Chen, Yuan, Chu, Qian, Yuan, Xianglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129991/
https://www.ncbi.nlm.nih.gov/pubmed/35620578
http://dx.doi.org/10.1155/2022/2586305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129991/
https://www.ncbi.nlm.nih.gov/pubmed/35620578
http://dx.doi.org/10.1155/2022/2586305

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