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Role of C-Reactive Protein in Diabetic Inflammation

Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. There is growing evidence that chronic subclinical inflammation...

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Autores principales: Stanimirovic, Julijana, Radovanovic, Jelena, Banjac, Katarina, Obradovic, Milan, Essack, Magbubah, Zafirovic, Sonja, Gluvic, Zoran, Gojobori, Takashi, Isenovic, Esma R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129992/
https://www.ncbi.nlm.nih.gov/pubmed/35620114
http://dx.doi.org/10.1155/2022/3706508
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author Stanimirovic, Julijana
Radovanovic, Jelena
Banjac, Katarina
Obradovic, Milan
Essack, Magbubah
Zafirovic, Sonja
Gluvic, Zoran
Gojobori, Takashi
Isenovic, Esma R.
author_facet Stanimirovic, Julijana
Radovanovic, Jelena
Banjac, Katarina
Obradovic, Milan
Essack, Magbubah
Zafirovic, Sonja
Gluvic, Zoran
Gojobori, Takashi
Isenovic, Esma R.
author_sort Stanimirovic, Julijana
collection PubMed
description Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. There is growing evidence that chronic subclinical inflammation is a triggering factor in the origin of T2DM. Increased C-reactive protein (CRP) levels have been linked to excess body weight since adipocytes produce tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), which are pivotal factors for CRP stimulation. Furthermore, it is known that hepatocytes produce relatively low rates of CRP in physiological conditions compared to T2DM patients, in which elevated levels of inflammatory markers are reported, including CRP. CRP also participates in endothelial dysfunction, the production of vasodilators, and vascular remodeling, and increased CRP level is closely associated with vascular system pathology and metabolic syndrome. In addition, insulin-based therapies may alter CRP levels in T2DM. Therefore, determining and clarifying the underlying CRP mechanism of T2DM is imperative for novel preventive and diagnostic procedures. Overall, CRP is one of the possible targets for T2DM progression and understanding the connection between insulin and inflammation may be helpful in clinical treatment and prevention approaches.
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spelling pubmed-91299922022-05-25 Role of C-Reactive Protein in Diabetic Inflammation Stanimirovic, Julijana Radovanovic, Jelena Banjac, Katarina Obradovic, Milan Essack, Magbubah Zafirovic, Sonja Gluvic, Zoran Gojobori, Takashi Isenovic, Esma R. Mediators Inflamm Review Article Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. There is growing evidence that chronic subclinical inflammation is a triggering factor in the origin of T2DM. Increased C-reactive protein (CRP) levels have been linked to excess body weight since adipocytes produce tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), which are pivotal factors for CRP stimulation. Furthermore, it is known that hepatocytes produce relatively low rates of CRP in physiological conditions compared to T2DM patients, in which elevated levels of inflammatory markers are reported, including CRP. CRP also participates in endothelial dysfunction, the production of vasodilators, and vascular remodeling, and increased CRP level is closely associated with vascular system pathology and metabolic syndrome. In addition, insulin-based therapies may alter CRP levels in T2DM. Therefore, determining and clarifying the underlying CRP mechanism of T2DM is imperative for novel preventive and diagnostic procedures. Overall, CRP is one of the possible targets for T2DM progression and understanding the connection between insulin and inflammation may be helpful in clinical treatment and prevention approaches. Hindawi 2022-05-17 /pmc/articles/PMC9129992/ /pubmed/35620114 http://dx.doi.org/10.1155/2022/3706508 Text en Copyright © 2022 Julijana Stanimirovic et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Stanimirovic, Julijana
Radovanovic, Jelena
Banjac, Katarina
Obradovic, Milan
Essack, Magbubah
Zafirovic, Sonja
Gluvic, Zoran
Gojobori, Takashi
Isenovic, Esma R.
Role of C-Reactive Protein in Diabetic Inflammation
title Role of C-Reactive Protein in Diabetic Inflammation
title_full Role of C-Reactive Protein in Diabetic Inflammation
title_fullStr Role of C-Reactive Protein in Diabetic Inflammation
title_full_unstemmed Role of C-Reactive Protein in Diabetic Inflammation
title_short Role of C-Reactive Protein in Diabetic Inflammation
title_sort role of c-reactive protein in diabetic inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129992/
https://www.ncbi.nlm.nih.gov/pubmed/35620114
http://dx.doi.org/10.1155/2022/3706508
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