CONVINCE in the context of existing evidence on haemodiafiltration

Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the compara...

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Autores principales: Vernooij, Robin W M, Bots, Michiel L, Strippoli, Giovanni F M, Canaud, Bernard, Cromm, Krister, Woodward, Mark, Blankestijn, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130023/
https://www.ncbi.nlm.nih.gov/pubmed/35098994
http://dx.doi.org/10.1093/ndt/gfac019
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author Vernooij, Robin W M
Bots, Michiel L
Strippoli, Giovanni F M
Canaud, Bernard
Cromm, Krister
Woodward, Mark
Blankestijn, Peter J
author_facet Vernooij, Robin W M
Bots, Michiel L
Strippoli, Giovanni F M
Canaud, Bernard
Cromm, Krister
Woodward, Mark
Blankestijn, Peter J
author_sort Vernooij, Robin W M
collection PubMed
description Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of ‘the comparison of high-dose HDF with high-flux HD’ (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease.
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spelling pubmed-91300232022-05-25 CONVINCE in the context of existing evidence on haemodiafiltration Vernooij, Robin W M Bots, Michiel L Strippoli, Giovanni F M Canaud, Bernard Cromm, Krister Woodward, Mark Blankestijn, Peter J Nephrol Dial Transplant Editorial Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of ‘the comparison of high-dose HDF with high-flux HD’ (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease. Oxford University Press 2022-01-31 /pmc/articles/PMC9130023/ /pubmed/35098994 http://dx.doi.org/10.1093/ndt/gfac019 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Editorial
Vernooij, Robin W M
Bots, Michiel L
Strippoli, Giovanni F M
Canaud, Bernard
Cromm, Krister
Woodward, Mark
Blankestijn, Peter J
CONVINCE in the context of existing evidence on haemodiafiltration
title CONVINCE in the context of existing evidence on haemodiafiltration
title_full CONVINCE in the context of existing evidence on haemodiafiltration
title_fullStr CONVINCE in the context of existing evidence on haemodiafiltration
title_full_unstemmed CONVINCE in the context of existing evidence on haemodiafiltration
title_short CONVINCE in the context of existing evidence on haemodiafiltration
title_sort convince in the context of existing evidence on haemodiafiltration
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130023/
https://www.ncbi.nlm.nih.gov/pubmed/35098994
http://dx.doi.org/10.1093/ndt/gfac019
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