Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Transcription factors ThPOK and Runx3 regulate the differentiation of “helper” CD4(+) and “cytotoxic” CD8(+) T cell lineages respectively, inducing single positive (SP) T cells that enter the periphery with the expression of either the CD4 or CD8 co-receptor. Despite the expectation that these cell...

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Detalles Bibliográficos
Autores principales: Schad, Sara E., Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X., Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M., Gainor, Justin F., Hellmann, Matthew D., Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N., Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D., Merghoub, Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130031/
https://www.ncbi.nlm.nih.gov/pubmed/35604411
http://dx.doi.org/10.1084/jem.20212169

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