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Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model
In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis(®) Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sp...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Association for Laboratory Animal Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130039/ https://www.ncbi.nlm.nih.gov/pubmed/34789616 http://dx.doi.org/10.1538/expanim.21-0049 |
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author | Asada, Yasuyuki Koshinuma, Shinya Mikami, Masaki Shirai, Yuuki Machida, Yoshisato Nakayama, Takahisa Kushima, Ryoji Yamamoto, Gaku Mukaisho, Ken-ichi |
author_facet | Asada, Yasuyuki Koshinuma, Shinya Mikami, Masaki Shirai, Yuuki Machida, Yoshisato Nakayama, Takahisa Kushima, Ryoji Yamamoto, Gaku Mukaisho, Ken-ichi |
author_sort | Asada, Yasuyuki |
collection | PubMed |
description | In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis(®) Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm(2) wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti-cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material. |
format | Online Article Text |
id | pubmed-9130039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91300392022-06-09 Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model Asada, Yasuyuki Koshinuma, Shinya Mikami, Masaki Shirai, Yuuki Machida, Yoshisato Nakayama, Takahisa Kushima, Ryoji Yamamoto, Gaku Mukaisho, Ken-ichi Exp Anim Original In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis(®) Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm(2) wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti-cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material. Japanese Association for Laboratory Animal Science 2021-11-18 2022 /pmc/articles/PMC9130039/ /pubmed/34789616 http://dx.doi.org/10.1538/expanim.21-0049 Text en ©2022 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Asada, Yasuyuki Koshinuma, Shinya Mikami, Masaki Shirai, Yuuki Machida, Yoshisato Nakayama, Takahisa Kushima, Ryoji Yamamoto, Gaku Mukaisho, Ken-ichi Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
title | Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
title_full | Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
title_fullStr | Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
title_full_unstemmed | Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
title_short | Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
title_sort | comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130039/ https://www.ncbi.nlm.nih.gov/pubmed/34789616 http://dx.doi.org/10.1538/expanim.21-0049 |
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