Changes in plasma-concentration ratios of branched-chain amino acids in acute and convalescent phases of bacterial pneumonia

Branched-chain amino acids (BCAAs) have different immunity-related functions. Thus, BCAAs require evaluation in terms of their plasma concentration ratio. Eighty healthy participants and 57 patients with community-acquired pneumonia were enrolled. Samples from the healthy participants were collected after 12-h fasting; samples from the community-acquired pneumonia group were collected 2–3 h after lunch, during the acute (day 0) and convalescent (day 7) phases. The coefficient “a” of the regression line (Y = aX + b) of each BCAA plasma concentration was calculated from healthy participants and fixed, and each intercept “b” was calculated from the plasma concentration of each BCAA pair. Isoleucine levels increased; no significant changes in leucine concentrations were observed between healthy participants and pneumonia patients on days 0 and 7. In female participants in the pneumonia group, valine concentrations decreased on day 0. The isoleucine concentration was relatively higher than the leucine concentration on day 7 when evaluated with “b”. Changes in “b” on days 0 and 7 differed between men and women. There were sex-related differences in the plasma concentration ratios of BCAAs evaluated by “b”, which indicates a possible sex-related difference in the metabolic response to bacterial infection.