Cargando…
A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy
Immune checkpoint blockade (ICB) therapies that target programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway are currently used for the treatment of various cancer types. However, low response rates of ICB remain the major issue and limit their applications in clinic. Here, w...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130108/ https://www.ncbi.nlm.nih.gov/pubmed/35647515 http://dx.doi.org/10.1016/j.mtbio.2022.100284 |
_version_ | 1784712916774158336 |
---|---|
author | Hu, Doudou Zhang, Wei Xiang, Jiajia Li, Dongdong Chen, Yong Yuan, Pengcheng Shao, Shiqun Zhou, Zhuxian Shen, Youqing Tang, Jianbin |
author_facet | Hu, Doudou Zhang, Wei Xiang, Jiajia Li, Dongdong Chen, Yong Yuan, Pengcheng Shao, Shiqun Zhou, Zhuxian Shen, Youqing Tang, Jianbin |
author_sort | Hu, Doudou |
collection | PubMed |
description | Immune checkpoint blockade (ICB) therapies that target programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway are currently used for the treatment of various cancer types. However, low response rates of ICB remain the major issue and limit their applications in clinic. Here, we developed a ROS-responsive synergistic delivery system (pep-PAPM@PTX) by integrating physically-encapsulated paclitaxel (PTX) and surface-modified anti-PD-L1 peptide (pep) for combined chemotherapy and ICB therapy. Pep-PAPM@PTX could bind the cell surface PD-L1 and drive its recycling to lysosomal degradation, thus reverting PTX-induced PD-L1 upregulation and downregulating PD-L1 expression. As a result, pep-PAPM@PTX significantly promoted T cell infiltration and increased tumor immunoactivating factors, synergizing PTX chemotherapy to achieve enhanced anticancer potency in a triple-negative breast cancer (TNBC) model. |
format | Online Article Text |
id | pubmed-9130108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-91301082022-05-26 A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy Hu, Doudou Zhang, Wei Xiang, Jiajia Li, Dongdong Chen, Yong Yuan, Pengcheng Shao, Shiqun Zhou, Zhuxian Shen, Youqing Tang, Jianbin Mater Today Bio Full Length Article Immune checkpoint blockade (ICB) therapies that target programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway are currently used for the treatment of various cancer types. However, low response rates of ICB remain the major issue and limit their applications in clinic. Here, we developed a ROS-responsive synergistic delivery system (pep-PAPM@PTX) by integrating physically-encapsulated paclitaxel (PTX) and surface-modified anti-PD-L1 peptide (pep) for combined chemotherapy and ICB therapy. Pep-PAPM@PTX could bind the cell surface PD-L1 and drive its recycling to lysosomal degradation, thus reverting PTX-induced PD-L1 upregulation and downregulating PD-L1 expression. As a result, pep-PAPM@PTX significantly promoted T cell infiltration and increased tumor immunoactivating factors, synergizing PTX chemotherapy to achieve enhanced anticancer potency in a triple-negative breast cancer (TNBC) model. Elsevier 2022-05-11 /pmc/articles/PMC9130108/ /pubmed/35647515 http://dx.doi.org/10.1016/j.mtbio.2022.100284 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Full Length Article Hu, Doudou Zhang, Wei Xiang, Jiajia Li, Dongdong Chen, Yong Yuan, Pengcheng Shao, Shiqun Zhou, Zhuxian Shen, Youqing Tang, Jianbin A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
title | A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
title_full | A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
title_fullStr | A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
title_full_unstemmed | A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
title_short | A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
title_sort | ros-responsive synergistic delivery system for combined immunotherapy and chemotherapy |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130108/ https://www.ncbi.nlm.nih.gov/pubmed/35647515 http://dx.doi.org/10.1016/j.mtbio.2022.100284 |
work_keys_str_mv | AT hudoudou arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT zhangwei arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT xiangjiajia arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT lidongdong arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT chenyong arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT yuanpengcheng arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT shaoshiqun arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT zhouzhuxian arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT shenyouqing arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT tangjianbin arosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT hudoudou rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT zhangwei rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT xiangjiajia rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT lidongdong rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT chenyong rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT yuanpengcheng rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT shaoshiqun rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT zhouzhuxian rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT shenyouqing rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy AT tangjianbin rosresponsivesynergisticdeliverysystemforcombinedimmunotherapyandchemotherapy |