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Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

Rev1 is a translesion DNA synthesis (TLS) polymerase involved in the bypass of adducted-guanine bases and abasic sites during DNA replication. During damage bypass, Rev1 utilizes a protein-template mechanism of DNA synthesis, where the templating DNA base is evicted from the Rev1 active site and rep...

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Detalles Bibliográficos
Autores principales:	Weaver, Tyler M., Click, Timothy H., Khoang, Thu H., Todd Washington, M., Agarwal, Pratul K., Freudenthal, Bret D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130138/ https://www.ncbi.nlm.nih.gov/pubmed/35610266 http://dx.doi.org/10.1038/s41467-022-30577-0

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