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Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China

Epidemiological evidence of the effect of high-level air pollution and its interaction with meteorological factors on the risk of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is limited. Daily data on AECOPD cases, air pollutants and meteorological factors were collected from...

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Autores principales: Song, Beibei, Zhang, Huiran, Jiao, Libin, Jing, Zeng, Li, Honglin, Wu, Siyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130147/
https://www.ncbi.nlm.nih.gov/pubmed/35610290
http://dx.doi.org/10.1038/s41598-022-12791-4
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author Song, Beibei
Zhang, Huiran
Jiao, Libin
Jing, Zeng
Li, Honglin
Wu, Siyu
author_facet Song, Beibei
Zhang, Huiran
Jiao, Libin
Jing, Zeng
Li, Honglin
Wu, Siyu
author_sort Song, Beibei
collection PubMed
description Epidemiological evidence of the effect of high-level air pollution and its interaction with meteorological factors on the risk of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is limited. Daily data on AECOPD cases, air pollutants and meteorological factors were collected from 2015 to 2018 in Shijiazhuang. A distributed lag non-linear model (DLNM) was used to explore the lag and cumulative effect of PM(2.5) on the risk of AECOPD. The effect of the interaction between PM(2.5) and meteorological factors on AECOPD was estimated by a generalized additive model (GAM) and a stratification model. A total of 4766 patients with AECOPD were enrolled. After controlling for confounders, each 10 μg/m(3) increase in PM(2.5) led to a 5.8% increase in the risk of AECOPD on day lag 0. The cumulative effect of PM(2.5) on AECOPD risk showed an increasing trend after 3 days. Similar results were observed in both smoking and non-smoking patients. There was an interaction between PM(2.5) and meteorological factors, and the risk of AECOPD was higher in cold and lower humidity conditions than in other conditions. High-level PM(2.5) exposure is positively associated with the risk of AECOPD onset, and the effect of PM(2.5) can be modified by the temperature and relative humidity. Public health guidelines should pay close attention to AECOPD risk under the condition of high-level PM(2.5) with low temperature or low humidity.
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spelling pubmed-91301472022-05-26 Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China Song, Beibei Zhang, Huiran Jiao, Libin Jing, Zeng Li, Honglin Wu, Siyu Sci Rep Article Epidemiological evidence of the effect of high-level air pollution and its interaction with meteorological factors on the risk of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is limited. Daily data on AECOPD cases, air pollutants and meteorological factors were collected from 2015 to 2018 in Shijiazhuang. A distributed lag non-linear model (DLNM) was used to explore the lag and cumulative effect of PM(2.5) on the risk of AECOPD. The effect of the interaction between PM(2.5) and meteorological factors on AECOPD was estimated by a generalized additive model (GAM) and a stratification model. A total of 4766 patients with AECOPD were enrolled. After controlling for confounders, each 10 μg/m(3) increase in PM(2.5) led to a 5.8% increase in the risk of AECOPD on day lag 0. The cumulative effect of PM(2.5) on AECOPD risk showed an increasing trend after 3 days. Similar results were observed in both smoking and non-smoking patients. There was an interaction between PM(2.5) and meteorological factors, and the risk of AECOPD was higher in cold and lower humidity conditions than in other conditions. High-level PM(2.5) exposure is positively associated with the risk of AECOPD onset, and the effect of PM(2.5) can be modified by the temperature and relative humidity. Public health guidelines should pay close attention to AECOPD risk under the condition of high-level PM(2.5) with low temperature or low humidity. Nature Publishing Group UK 2022-05-24 /pmc/articles/PMC9130147/ /pubmed/35610290 http://dx.doi.org/10.1038/s41598-022-12791-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Song, Beibei
Zhang, Huiran
Jiao, Libin
Jing, Zeng
Li, Honglin
Wu, Siyu
Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China
title Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China
title_full Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China
title_fullStr Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China
title_full_unstemmed Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China
title_short Effect of high-level fine particulate matter and its interaction with meteorological factors on AECOPD in Shijiazhuang, China
title_sort effect of high-level fine particulate matter and its interaction with meteorological factors on aecopd in shijiazhuang, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130147/
https://www.ncbi.nlm.nih.gov/pubmed/35610290
http://dx.doi.org/10.1038/s41598-022-12791-4
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