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Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment

Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo PD. It is associated with greater cognitive impairment and brain atrophy. However, the relation between structural brain characteristics and cognition re...

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Autores principales: Oltra, Javier, Uribe, Carme, Segura, Barbara, Campabadal, Anna, Inguanzo, Anna, Monté-Rubio, Gemma C., Pardo, Jèssica, Marti, Maria J., Compta, Yaroslau, Valldeoriola, Francesc, Junque, Carme, Iranzo, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130201/
https://www.ncbi.nlm.nih.gov/pubmed/35610256
http://dx.doi.org/10.1038/s41531-022-00326-7
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author Oltra, Javier
Uribe, Carme
Segura, Barbara
Campabadal, Anna
Inguanzo, Anna
Monté-Rubio, Gemma C.
Pardo, Jèssica
Marti, Maria J.
Compta, Yaroslau
Valldeoriola, Francesc
Junque, Carme
Iranzo, Alex
author_facet Oltra, Javier
Uribe, Carme
Segura, Barbara
Campabadal, Anna
Inguanzo, Anna
Monté-Rubio, Gemma C.
Pardo, Jèssica
Marti, Maria J.
Compta, Yaroslau
Valldeoriola, Francesc
Junque, Carme
Iranzo, Alex
author_sort Oltra, Javier
collection PubMed
description Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo PD. It is associated with greater cognitive impairment and brain atrophy. However, the relation between structural brain characteristics and cognition remains poorly understood. We aimed to investigate subcortical and cortical atrophy in de novo PD with probable RBD (PD-pRBD) and to relate it with cognitive impairment. We analyzed volumetry, cortical thickness, and cognitive measures from 79 PD-pRBD patients, 126 PD without probable RBD patients (PD-non pRBD), and 69 controls from the Parkinson’s Progression Markers Initiative (PPMI). Regression models of cognition were tested using magnetic resonance imaging measures as predictors. We found lower left thalamus volume in PD-pRBD compared with PD-non pRBD. Compared with controls, PD-pRBD group showed atrophy in the bilateral putamen, left hippocampus, left amygdala, and thinning in the right superior temporal gyrus. Specific deep gray matter nuclei volumes were associated with impairment in global cognition, phonemic fluency, processing speed, and visuospatial function in PD-pRBD. In conclusion, cognitive impairment and gray matter atrophy are already present in de novo PD-pRBD. Thalamus, hippocampus, and putamen volumes were mainly associated with these cognitive deficits.
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spelling pubmed-91302012022-05-26 Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment Oltra, Javier Uribe, Carme Segura, Barbara Campabadal, Anna Inguanzo, Anna Monté-Rubio, Gemma C. Pardo, Jèssica Marti, Maria J. Compta, Yaroslau Valldeoriola, Francesc Junque, Carme Iranzo, Alex NPJ Parkinsons Dis Article Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo PD. It is associated with greater cognitive impairment and brain atrophy. However, the relation between structural brain characteristics and cognition remains poorly understood. We aimed to investigate subcortical and cortical atrophy in de novo PD with probable RBD (PD-pRBD) and to relate it with cognitive impairment. We analyzed volumetry, cortical thickness, and cognitive measures from 79 PD-pRBD patients, 126 PD without probable RBD patients (PD-non pRBD), and 69 controls from the Parkinson’s Progression Markers Initiative (PPMI). Regression models of cognition were tested using magnetic resonance imaging measures as predictors. We found lower left thalamus volume in PD-pRBD compared with PD-non pRBD. Compared with controls, PD-pRBD group showed atrophy in the bilateral putamen, left hippocampus, left amygdala, and thinning in the right superior temporal gyrus. Specific deep gray matter nuclei volumes were associated with impairment in global cognition, phonemic fluency, processing speed, and visuospatial function in PD-pRBD. In conclusion, cognitive impairment and gray matter atrophy are already present in de novo PD-pRBD. Thalamus, hippocampus, and putamen volumes were mainly associated with these cognitive deficits. Nature Publishing Group UK 2022-05-24 /pmc/articles/PMC9130201/ /pubmed/35610256 http://dx.doi.org/10.1038/s41531-022-00326-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Oltra, Javier
Uribe, Carme
Segura, Barbara
Campabadal, Anna
Inguanzo, Anna
Monté-Rubio, Gemma C.
Pardo, Jèssica
Marti, Maria J.
Compta, Yaroslau
Valldeoriola, Francesc
Junque, Carme
Iranzo, Alex
Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
title Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
title_full Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
title_fullStr Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
title_full_unstemmed Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
title_short Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
title_sort brain atrophy pattern in de novo parkinson’s disease with probable rbd associated with cognitive impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130201/
https://www.ncbi.nlm.nih.gov/pubmed/35610256
http://dx.doi.org/10.1038/s41531-022-00326-7
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