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Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

Brain radiation necrosis (RN) or neurocognitive disorder is a severe adverse effect that may occur after radiation therapy for malignant brain tumors or head and neck cancers. RN accompanies inflammation which causes edema or micro-bleeding, and no fundamental treatment has been developed. In inflam...

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Detalles Bibliográficos
Autores principales:	Kondo, Natsuko, Sakurai, Yoshinori, Takata, Takushi, Kano, Kuniyuki, Kume, Kyo, Maeda, Munetoshi, Takai, Nobuhiko, Suzuki, Shugo, Eto, Fumihiro, Kikushima, Kenji, Wanibuchi, Hideki, Miyatake, Shin-Ichi, Kajihara, Takayuki, Oda, Shoji, Setou, Mitsutoshi, Aoki, Junken, Suzuki, Minoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130232/ https://www.ncbi.nlm.nih.gov/pubmed/35610277 http://dx.doi.org/10.1038/s41598-022-12293-3

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