Targeting aberrant replication and DNA repair events for treating breast cancers

The major limitations of DNA-targeting chemotherapy drugs include life-threatening toxicity, acquired resistance and occurrence of secondary cancers. Here, we report a small molecule, Carbazole Blue (CB), that binds to DNA and inhibits cancer growth and metastasis by targeting DNA-related processes...

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Detalles Bibliográficos
Autores principales: Rajamanickam, Subapriya, Park, Jun Hyoung, Subbarayalu, Panneerdoss, Timilsina, Santosh, Bates, Kaitlyn, Yadav, Pooja, Nirzhor, Saif S. R., Eedunuri, Vijay, Mohammad, Tabrez A., Jung, Kwang Hwa, Onyeagucha, Benjamin, Abdelfattah, Nourhan, Benevides, Raymond, Lee, Grace, Chen, Yidong, Vadlamudi, Ratna, Brenner, Andrew, Kaklamani, Virginia, Jatoi, Ismail, Kuhn, John, Hromas, Robert, Gupta, Yogesh K., Kaipparettu, Benny A., Arbiser, Jack L., Rao, Manjeet K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130234/
https://www.ncbi.nlm.nih.gov/pubmed/35610507
http://dx.doi.org/10.1038/s42003-022-03413-w

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