Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate various genes involved in cholesterol and fatty acid synthesis. In this study, we describe that naturally occurring isothiocyanate sulforaphane (SFaN) impairs fatty acid synthase promoter activity and reduces...

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Detalles Bibliográficos
Autores principales: Miyata, Shingo, Kodaka, Manami, Kikuchi, Akito, Matsunaga, Yuki, Shoji, Kenta, Kuan, Yen-Chou, Iwase, Masamori, Takeda, Keita, Katsuta, Ryo, Ishigami, Ken, Matsumoto, Yu, Suzuki, Tsukasa, Yamamoto, Yuji, Sato, Ryuichiro, Inoue, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130306/
https://www.ncbi.nlm.nih.gov/pubmed/35610278
http://dx.doi.org/10.1038/s41598-022-12347-6

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