Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols

The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. However, some receptors, including the mu opioid receptor, are non-functional, which may be due to the presence of the fungal sterol ergosterol instead of chole...

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Detalles Bibliográficos
Autores principales: Bean, Björn D. M., Mulvihill, Colleen J., Garge, Riddhiman K., Boutz, Daniel R., Rousseau, Olivier, Floyd, Brendan M., Cheney, William, Gardner, Elizabeth C., Ellington, Andrew D., Marcotte, Edward M., Gollihar, Jimmy D., Whiteway, Malcolm, Martin, Vincent J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130329/
https://www.ncbi.nlm.nih.gov/pubmed/35610225
http://dx.doi.org/10.1038/s41467-022-30570-7

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