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Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor

Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people suffer seizures caused by neurological abnorm...

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Autores principales: Muto, Nilton Akio, Hamoy, Moisés, da Silva Ferreira, Chryslen Brenda, Hamoy, Akira Otake, Lucas, David Cristian Rodrigues, de Mello, Vanessa Jóia, Rogez, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130464/
https://www.ncbi.nlm.nih.gov/pubmed/35634465
http://dx.doi.org/10.3389/fncel.2022.872743
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author Muto, Nilton Akio
Hamoy, Moisés
da Silva Ferreira, Chryslen Brenda
Hamoy, Akira Otake
Lucas, David Cristian Rodrigues
de Mello, Vanessa Jóia
Rogez, Hervé
author_facet Muto, Nilton Akio
Hamoy, Moisés
da Silva Ferreira, Chryslen Brenda
Hamoy, Akira Otake
Lucas, David Cristian Rodrigues
de Mello, Vanessa Jóia
Rogez, Hervé
author_sort Muto, Nilton Akio
collection PubMed
description Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people suffer seizures caused by neurological abnormalities. Approximately 80% of all epileptic patients reside in low-income conditions or in developing countries, and over 75% of patients do not receive proper treatment. Our previous study found an anticonvulsant property of an extract of Euterpe oleracea stone (EEOS) that caused myorelaxation, sedation, and cardiac and respiratory depression after intraperitoneal administration. The present study investigated through electroencephalographic (EEG) profiling the anticonvulsant protective properties of EEOS in induced convulsing rats. Male Wistar rats were treated with EEOS (300 mg/kg), diazepam (DZP) (5 mg/kg), pentylenetetrazol (PTZ) (60 mg/kg) and flumazenil (FMZ) (0.1 mg/kg) by intraperitoneal (i.p.). Electrodes implanted on the dura mater provided EEG data in which EEOS suppressed seizure deflagration caused by PTZ. In addition, EEOS presented no significant difference in comparison to DZP, which has the same mechanism of action. After FMZ injection, a GABAA receptor antagonist blocked the anticonvulsive effect in both the DZP and EEOS groups, suggesting that EEOS exerts it action on the GABAA receptor at the benzodiazepine (BDZ) subunit.
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spelling pubmed-91304642022-05-26 Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor Muto, Nilton Akio Hamoy, Moisés da Silva Ferreira, Chryslen Brenda Hamoy, Akira Otake Lucas, David Cristian Rodrigues de Mello, Vanessa Jóia Rogez, Hervé Front Cell Neurosci Neuroscience Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people suffer seizures caused by neurological abnormalities. Approximately 80% of all epileptic patients reside in low-income conditions or in developing countries, and over 75% of patients do not receive proper treatment. Our previous study found an anticonvulsant property of an extract of Euterpe oleracea stone (EEOS) that caused myorelaxation, sedation, and cardiac and respiratory depression after intraperitoneal administration. The present study investigated through electroencephalographic (EEG) profiling the anticonvulsant protective properties of EEOS in induced convulsing rats. Male Wistar rats were treated with EEOS (300 mg/kg), diazepam (DZP) (5 mg/kg), pentylenetetrazol (PTZ) (60 mg/kg) and flumazenil (FMZ) (0.1 mg/kg) by intraperitoneal (i.p.). Electrodes implanted on the dura mater provided EEG data in which EEOS suppressed seizure deflagration caused by PTZ. In addition, EEOS presented no significant difference in comparison to DZP, which has the same mechanism of action. After FMZ injection, a GABAA receptor antagonist blocked the anticonvulsive effect in both the DZP and EEOS groups, suggesting that EEOS exerts it action on the GABAA receptor at the benzodiazepine (BDZ) subunit. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9130464/ /pubmed/35634465 http://dx.doi.org/10.3389/fncel.2022.872743 Text en Copyright © 2022 Muto, Hamoy, da Silva Ferreira, Hamoy, Lucas, de Mello and Rogez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Muto, Nilton Akio
Hamoy, Moisés
da Silva Ferreira, Chryslen Brenda
Hamoy, Akira Otake
Lucas, David Cristian Rodrigues
de Mello, Vanessa Jóia
Rogez, Hervé
Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
title Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
title_full Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
title_fullStr Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
title_full_unstemmed Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
title_short Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
title_sort extract of euterpe oleracea martius stone presents anticonvulsive activity via the gabaa receptor
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130464/
https://www.ncbi.nlm.nih.gov/pubmed/35634465
http://dx.doi.org/10.3389/fncel.2022.872743
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