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The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases

An effective acute inflammatory response results in the elimination of infectious microorganisms, followed by a smooth transition to resolution and repair. During the inflammatory response, neutrophils play a crucial role in antimicrobial defense as the first cells to reach the site of infection dam...

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Autores principales: Wang, Yongbo, Liu, Xingyu, Xia, Panpan, Li, Zhangwang, FuChen, Xinxi, Shen, Yunfeng, Yu, Peng, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130478/
https://www.ncbi.nlm.nih.gov/pubmed/35634335
http://dx.doi.org/10.3389/fimmu.2022.901166
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author Wang, Yongbo
Liu, Xingyu
Xia, Panpan
Li, Zhangwang
FuChen, Xinxi
Shen, Yunfeng
Yu, Peng
Zhang, Jing
author_facet Wang, Yongbo
Liu, Xingyu
Xia, Panpan
Li, Zhangwang
FuChen, Xinxi
Shen, Yunfeng
Yu, Peng
Zhang, Jing
author_sort Wang, Yongbo
collection PubMed
description An effective acute inflammatory response results in the elimination of infectious microorganisms, followed by a smooth transition to resolution and repair. During the inflammatory response, neutrophils play a crucial role in antimicrobial defense as the first cells to reach the site of infection damage. However, if the neutrophils that have performed the bactericidal effect are not removed in time, the inflammatory response will not be able to subside. Anti-inflammatory macrophages are the main scavengers of neutrophils and can promote inflammation towards resolution. MicroRNAs (miRNAs) have great potential as clinical targeted therapy and have attracted much attention in recent years. This paper summarizes the involvement of miRNAs in the process of chronic diseases such as atherosclerosis, rheumatoid arthritis and systemic lupus erythematosus by regulating lipid metabolism, cytokine secretion, inflammatory factor synthesis and tissue repair in two types of cells. This will provide a certain reference for miRNA-targeted treatment of chronic diseases.
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spelling pubmed-91304782022-05-26 The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases Wang, Yongbo Liu, Xingyu Xia, Panpan Li, Zhangwang FuChen, Xinxi Shen, Yunfeng Yu, Peng Zhang, Jing Front Immunol Immunology An effective acute inflammatory response results in the elimination of infectious microorganisms, followed by a smooth transition to resolution and repair. During the inflammatory response, neutrophils play a crucial role in antimicrobial defense as the first cells to reach the site of infection damage. However, if the neutrophils that have performed the bactericidal effect are not removed in time, the inflammatory response will not be able to subside. Anti-inflammatory macrophages are the main scavengers of neutrophils and can promote inflammation towards resolution. MicroRNAs (miRNAs) have great potential as clinical targeted therapy and have attracted much attention in recent years. This paper summarizes the involvement of miRNAs in the process of chronic diseases such as atherosclerosis, rheumatoid arthritis and systemic lupus erythematosus by regulating lipid metabolism, cytokine secretion, inflammatory factor synthesis and tissue repair in two types of cells. This will provide a certain reference for miRNA-targeted treatment of chronic diseases. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9130478/ /pubmed/35634335 http://dx.doi.org/10.3389/fimmu.2022.901166 Text en Copyright © 2022 Wang, Liu, Xia, Li, FuChen, Shen, Yu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Yongbo
Liu, Xingyu
Xia, Panpan
Li, Zhangwang
FuChen, Xinxi
Shen, Yunfeng
Yu, Peng
Zhang, Jing
The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
title The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
title_full The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
title_fullStr The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
title_full_unstemmed The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
title_short The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
title_sort regulatory role of micrornas on phagocytes: a potential therapeutic target for chronic diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130478/
https://www.ncbi.nlm.nih.gov/pubmed/35634335
http://dx.doi.org/10.3389/fimmu.2022.901166
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