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Off-season RSV epidemics in Australia after easing of COVID-19 restrictions

Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection with the most severe disease in the young and elderly. Non-pharmaceutical interventions and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RS...

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Autores principales: Eden, John-Sebastian, Sikazwe, Chisha, Xie, Ruopeng, Deng, Yi-Mo, Sullivan, Sheena G., Michie, Alice, Levy, Avram, Cutmore, Elena, Blyth, Christopher C., Britton, Philip N., Crawford, Nigel, Dong, Xiaomin, Dwyer, Dominic E., Edwards, Kimberly M., Horsburgh, Bethany A., Foley, David, Kennedy, Karina, Minney-Smith, Cara, Speers, David, Tulloch, Rachel L., Holmes, Edward C., Dhanasekaran, Vijaykrishna, Smith, David W., Kok, Jen, Barr, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130497/
https://www.ncbi.nlm.nih.gov/pubmed/35610217
http://dx.doi.org/10.1038/s41467-022-30485-3
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author Eden, John-Sebastian
Sikazwe, Chisha
Xie, Ruopeng
Deng, Yi-Mo
Sullivan, Sheena G.
Michie, Alice
Levy, Avram
Cutmore, Elena
Blyth, Christopher C.
Britton, Philip N.
Crawford, Nigel
Dong, Xiaomin
Dwyer, Dominic E.
Edwards, Kimberly M.
Horsburgh, Bethany A.
Foley, David
Kennedy, Karina
Minney-Smith, Cara
Speers, David
Tulloch, Rachel L.
Holmes, Edward C.
Dhanasekaran, Vijaykrishna
Smith, David W.
Kok, Jen
Barr, Ian G.
author_facet Eden, John-Sebastian
Sikazwe, Chisha
Xie, Ruopeng
Deng, Yi-Mo
Sullivan, Sheena G.
Michie, Alice
Levy, Avram
Cutmore, Elena
Blyth, Christopher C.
Britton, Philip N.
Crawford, Nigel
Dong, Xiaomin
Dwyer, Dominic E.
Edwards, Kimberly M.
Horsburgh, Bethany A.
Foley, David
Kennedy, Karina
Minney-Smith, Cara
Speers, David
Tulloch, Rachel L.
Holmes, Edward C.
Dhanasekaran, Vijaykrishna
Smith, David W.
Kok, Jen
Barr, Ian G.
author_sort Eden, John-Sebastian
collection PubMed
description Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection with the most severe disease in the young and elderly. Non-pharmaceutical interventions and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RSV globally, particularly in Australia, where during 2020 the normal winter epidemics were notably absent. However, in late 2020, unprecedented widespread RSV outbreaks occurred, beginning in spring, and extending into summer across two widely separated regions of the Australian continent, New South Wales (NSW) and Australian Capital Territory (ACT) in the east, and Western Australia. Through genomic sequencing we reveal a major reduction in RSV genetic diversity following COVID-19 emergence with two genetically distinct RSV-A clades circulating cryptically, likely localised for several months prior to an epidemic surge in cases upon relaxation of COVID-19 control measures. The NSW/ACT clade subsequently spread to the neighbouring state of Victoria and to cause extensive outbreaks and hospitalisations in early 2021. These findings highlight the need for continued surveillance and sequencing of RSV and other respiratory viruses during and after the COVID-19 pandemic, as mitigation measures may disrupt seasonal patterns, causing larger or more severe outbreaks.
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spelling pubmed-91304972022-05-26 Off-season RSV epidemics in Australia after easing of COVID-19 restrictions Eden, John-Sebastian Sikazwe, Chisha Xie, Ruopeng Deng, Yi-Mo Sullivan, Sheena G. Michie, Alice Levy, Avram Cutmore, Elena Blyth, Christopher C. Britton, Philip N. Crawford, Nigel Dong, Xiaomin Dwyer, Dominic E. Edwards, Kimberly M. Horsburgh, Bethany A. Foley, David Kennedy, Karina Minney-Smith, Cara Speers, David Tulloch, Rachel L. Holmes, Edward C. Dhanasekaran, Vijaykrishna Smith, David W. Kok, Jen Barr, Ian G. Nat Commun Article Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection with the most severe disease in the young and elderly. Non-pharmaceutical interventions and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RSV globally, particularly in Australia, where during 2020 the normal winter epidemics were notably absent. However, in late 2020, unprecedented widespread RSV outbreaks occurred, beginning in spring, and extending into summer across two widely separated regions of the Australian continent, New South Wales (NSW) and Australian Capital Territory (ACT) in the east, and Western Australia. Through genomic sequencing we reveal a major reduction in RSV genetic diversity following COVID-19 emergence with two genetically distinct RSV-A clades circulating cryptically, likely localised for several months prior to an epidemic surge in cases upon relaxation of COVID-19 control measures. The NSW/ACT clade subsequently spread to the neighbouring state of Victoria and to cause extensive outbreaks and hospitalisations in early 2021. These findings highlight the need for continued surveillance and sequencing of RSV and other respiratory viruses during and after the COVID-19 pandemic, as mitigation measures may disrupt seasonal patterns, causing larger or more severe outbreaks. Nature Publishing Group UK 2022-05-24 /pmc/articles/PMC9130497/ /pubmed/35610217 http://dx.doi.org/10.1038/s41467-022-30485-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Eden, John-Sebastian
Sikazwe, Chisha
Xie, Ruopeng
Deng, Yi-Mo
Sullivan, Sheena G.
Michie, Alice
Levy, Avram
Cutmore, Elena
Blyth, Christopher C.
Britton, Philip N.
Crawford, Nigel
Dong, Xiaomin
Dwyer, Dominic E.
Edwards, Kimberly M.
Horsburgh, Bethany A.
Foley, David
Kennedy, Karina
Minney-Smith, Cara
Speers, David
Tulloch, Rachel L.
Holmes, Edward C.
Dhanasekaran, Vijaykrishna
Smith, David W.
Kok, Jen
Barr, Ian G.
Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
title Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
title_full Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
title_fullStr Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
title_full_unstemmed Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
title_short Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
title_sort off-season rsv epidemics in australia after easing of covid-19 restrictions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130497/
https://www.ncbi.nlm.nih.gov/pubmed/35610217
http://dx.doi.org/10.1038/s41467-022-30485-3
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