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Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by accumulation of misfolded proteins. Genetic studies implicate microglia, brain-resident phagocytic immune cells, in AD pathogenesis. As positive effectors, microglia clear toxic proteins, whereas as negative effectors, they release proinflammatory mediato...

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Detalles Bibliográficos
Autores principales:	Gonzalez-Gil, Anabel, Porell, Ryan N., Fernandes, Steve M., Maenpaa, Eila, Li, T. August, Li, Tong, Wong, Philip C., Aoki, Kazuhiro, Tiemeyer, Michael, Yu, Zaikuan J., Orsburn, Benjamin C., Bumpus, Namandjé N., Matthews, Russell T., Schnaar, Ronald L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130525/ https://www.ncbi.nlm.nih.gov/pubmed/35452678 http://dx.doi.org/10.1016/j.jbc.2022.101960

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