Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1

Organic cation transporter 1 (OCT1) is a membrane transporter that affects hepatic uptake of cationic and weakly basic drugs. OCT1 transports structurally highly diverse substrates. The mechanisms conferring this polyspecificity are unknown. Here, we analyzed differences in transport kinetics betwee...

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Detalles Bibliográficos
Autores principales: Meyer, Marleen J., Schreier, Pascale C.F., Basaran, Mert, Vlasova, Stefaniia, Seitz, Tina, Brockmöller, Jürgen, Zdrazil, Barbara, Tzvetkov, Mladen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130538/
https://www.ncbi.nlm.nih.gov/pubmed/35469921
http://dx.doi.org/10.1016/j.jbc.2022.101974

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