Yeast cells depleted of the frataxin homolog Yfh1 redistribute cellular iron: Studies using Mössbauer spectroscopy and mathematical modeling

The neurodegenerative disease Friedreich’s ataxia arises from a deficiency of frataxin, a protein that promotes iron–sulfur cluster (ISC) assembly in mitochondria. Here, primarily using Mössbauer spectroscopy, we investigated the iron content of a yeast strain in which expression of yeast frataxin h...

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Detalles Bibliográficos
Autores principales: Fernandez, Salvador, Wofford, Joshua D., Shepherd, Rachel E., Vali, Shaik Waseem, Dancis, Andrew, Lindahl, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130540/
https://www.ncbi.nlm.nih.gov/pubmed/35413285
http://dx.doi.org/10.1016/j.jbc.2022.101921

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