Cargando…

Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a series of pathologic conditions including cancer. MicroRNA (miRNA) has been considered as a regulator in different tumor microenvironments. Recent studies have begun to unravel the crosstalk between m...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Lifei, Xu, Xiaoqing, Li, Jiawei, Yang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130582/
https://www.ncbi.nlm.nih.gov/pubmed/35634311
http://dx.doi.org/10.3389/fimmu.2022.883683
_version_ 1784713003728371712
author Liang, Lifei
Xu, Xiaoqing
Li, Jiawei
Yang, Cheng
author_facet Liang, Lifei
Xu, Xiaoqing
Li, Jiawei
Yang, Cheng
author_sort Liang, Lifei
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a series of pathologic conditions including cancer. MicroRNA (miRNA) has been considered as a regulator in different tumor microenvironments. Recent studies have begun to unravel the crosstalk between miRNAs and MDSCs. The knowledge of the effect of both miRNAs and MDSCs in tumor may improve our understanding of the tumor immune escape and metastasis. The miRNAs target cellular signal pathways to promote or inhibit the function of MDSCs. On the other hand, MDSCs transfer bioinformation through exosomes containing miRNAs. In this review, we summarized and discussed the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment.
format Online
Article
Text
id pubmed-9130582
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91305822022-05-26 Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment Liang, Lifei Xu, Xiaoqing Li, Jiawei Yang, Cheng Front Immunol Immunology Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a series of pathologic conditions including cancer. MicroRNA (miRNA) has been considered as a regulator in different tumor microenvironments. Recent studies have begun to unravel the crosstalk between miRNAs and MDSCs. The knowledge of the effect of both miRNAs and MDSCs in tumor may improve our understanding of the tumor immune escape and metastasis. The miRNAs target cellular signal pathways to promote or inhibit the function of MDSCs. On the other hand, MDSCs transfer bioinformation through exosomes containing miRNAs. In this review, we summarized and discussed the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9130582/ /pubmed/35634311 http://dx.doi.org/10.3389/fimmu.2022.883683 Text en Copyright © 2022 Liang, Xu, Li and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liang, Lifei
Xu, Xiaoqing
Li, Jiawei
Yang, Cheng
Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment
title Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment
title_full Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment
title_fullStr Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment
title_full_unstemmed Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment
title_short Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment
title_sort interaction between micrornas and myeloid-derived suppressor cells in tumor microenvironment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130582/
https://www.ncbi.nlm.nih.gov/pubmed/35634311
http://dx.doi.org/10.3389/fimmu.2022.883683
work_keys_str_mv AT lianglifei interactionbetweenmicrornasandmyeloidderivedsuppressorcellsintumormicroenvironment
AT xuxiaoqing interactionbetweenmicrornasandmyeloidderivedsuppressorcellsintumormicroenvironment
AT lijiawei interactionbetweenmicrornasandmyeloidderivedsuppressorcellsintumormicroenvironment
AT yangcheng interactionbetweenmicrornasandmyeloidderivedsuppressorcellsintumormicroenvironment