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Post COVID-19 Condition in Children and Adolescents: An Emerging Problem
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 million deaths worldwide. Several acute and long-term symptoms have been reported in infected adults, but it remains unclear whethe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130634/ https://www.ncbi.nlm.nih.gov/pubmed/35633949 http://dx.doi.org/10.3389/fped.2022.894204 |
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author | Izquierdo-Pujol, Jon Moron-Lopez, Sara Dalmau, Judith Gonzalez-Aumatell, Alba Carreras-Abad, Clara Mendez, Maria Rodrigo, Carlos Martinez-Picado, Javier |
author_facet | Izquierdo-Pujol, Jon Moron-Lopez, Sara Dalmau, Judith Gonzalez-Aumatell, Alba Carreras-Abad, Clara Mendez, Maria Rodrigo, Carlos Martinez-Picado, Javier |
author_sort | Izquierdo-Pujol, Jon |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 million deaths worldwide. Several acute and long-term symptoms have been reported in infected adults, but it remains unclear whether children/adolescents also experience persistent sequelae. Hence, we conducted a review of symptoms and pathophysiology associated with post-coronavirus disease 2019 (post-COVID-19) condition in children and adolescents. We reviewed the scientific literature for reports on persistent COVID-19 symptoms after SARS-CoV-2 infection in both children/adolescents and adults from 1 January 2020 to 31 March 2022 (based on their originality and relevance to the broad scope of this review, 26 reports were included, 8 focused on adults and 18 on children/adolescents). Persistent sequelae of COVID-19 are less common in children/adolescents than in adults, possibly owing to a lower frequency of SARS-CoV-2 infection and to the lower impact of the infection itself in this age group. However, cumulative evidence has shown prolonged COVID-19 to be a clinical entity, with few pathophysiological associations at present. The most common post-COVID-19 symptoms in children/adolescents are fatigue, lack of concentration, and muscle pain. In addition, we found evidence of pathophysiology associated with fatigue and/or headache, persistent loss of smell and cough, and neurological and/or cardiovascular symptoms. This review highlights the importance of unraveling why SARS-CoV-2 infection may cause post-COVID-19 condition and how persistent symptoms might affect the physical, social, and psychological well-being of young people in the future. |
format | Online Article Text |
id | pubmed-9130634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91306342022-05-26 Post COVID-19 Condition in Children and Adolescents: An Emerging Problem Izquierdo-Pujol, Jon Moron-Lopez, Sara Dalmau, Judith Gonzalez-Aumatell, Alba Carreras-Abad, Clara Mendez, Maria Rodrigo, Carlos Martinez-Picado, Javier Front Pediatr Pediatrics The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 million deaths worldwide. Several acute and long-term symptoms have been reported in infected adults, but it remains unclear whether children/adolescents also experience persistent sequelae. Hence, we conducted a review of symptoms and pathophysiology associated with post-coronavirus disease 2019 (post-COVID-19) condition in children and adolescents. We reviewed the scientific literature for reports on persistent COVID-19 symptoms after SARS-CoV-2 infection in both children/adolescents and adults from 1 January 2020 to 31 March 2022 (based on their originality and relevance to the broad scope of this review, 26 reports were included, 8 focused on adults and 18 on children/adolescents). Persistent sequelae of COVID-19 are less common in children/adolescents than in adults, possibly owing to a lower frequency of SARS-CoV-2 infection and to the lower impact of the infection itself in this age group. However, cumulative evidence has shown prolonged COVID-19 to be a clinical entity, with few pathophysiological associations at present. The most common post-COVID-19 symptoms in children/adolescents are fatigue, lack of concentration, and muscle pain. In addition, we found evidence of pathophysiology associated with fatigue and/or headache, persistent loss of smell and cough, and neurological and/or cardiovascular symptoms. This review highlights the importance of unraveling why SARS-CoV-2 infection may cause post-COVID-19 condition and how persistent symptoms might affect the physical, social, and psychological well-being of young people in the future. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9130634/ /pubmed/35633949 http://dx.doi.org/10.3389/fped.2022.894204 Text en Copyright © 2022 Izquierdo-Pujol, Moron-Lopez, Dalmau, Gonzalez-Aumatell, Carreras-Abad, Mendez, Rodrigo and Martinez-Picado. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Izquierdo-Pujol, Jon Moron-Lopez, Sara Dalmau, Judith Gonzalez-Aumatell, Alba Carreras-Abad, Clara Mendez, Maria Rodrigo, Carlos Martinez-Picado, Javier Post COVID-19 Condition in Children and Adolescents: An Emerging Problem |
title | Post COVID-19 Condition in Children and Adolescents: An Emerging Problem |
title_full | Post COVID-19 Condition in Children and Adolescents: An Emerging Problem |
title_fullStr | Post COVID-19 Condition in Children and Adolescents: An Emerging Problem |
title_full_unstemmed | Post COVID-19 Condition in Children and Adolescents: An Emerging Problem |
title_short | Post COVID-19 Condition in Children and Adolescents: An Emerging Problem |
title_sort | post covid-19 condition in children and adolescents: an emerging problem |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130634/ https://www.ncbi.nlm.nih.gov/pubmed/35633949 http://dx.doi.org/10.3389/fped.2022.894204 |
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