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Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea

Women frequently report increased bloating, flatulence, and pain during the perimenstrual period. However, it is unknown whether women have more intraluminal gas during menses. To evaluate whether pain-free women or women with dysmenorrhea have different amounts of intraluminal bowel gas during the...

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Autores principales: Oh, Hyeyoung, Ehrenpreis, Eli D., Tu, Frank F., Dillane, Katlyn E., Garrison, Ellen F., Leloudas, Nondas, Prasad, Pottumarthi V., Hellman, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130698/
https://www.ncbi.nlm.nih.gov/pubmed/35634451
http://dx.doi.org/10.3389/fpain.2022.720141
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author Oh, Hyeyoung
Ehrenpreis, Eli D.
Tu, Frank F.
Dillane, Katlyn E.
Garrison, Ellen F.
Leloudas, Nondas
Prasad, Pottumarthi V.
Hellman, Kevin M.
author_facet Oh, Hyeyoung
Ehrenpreis, Eli D.
Tu, Frank F.
Dillane, Katlyn E.
Garrison, Ellen F.
Leloudas, Nondas
Prasad, Pottumarthi V.
Hellman, Kevin M.
author_sort Oh, Hyeyoung
collection PubMed
description Women frequently report increased bloating, flatulence, and pain during the perimenstrual period. However, it is unknown whether women have more intraluminal gas during menses. To evaluate whether pain-free women or women with dysmenorrhea have different amounts of intraluminal bowel gas during the menses, we utilized magnetic resonance imaging (MRI) to determine colonic gas volumes throughout the menstrual cycle. To avoid dietary influence, the participants were instructed to avoid gas-producing foods before their scheduled MRI. We verified the measurement repeatability across the reviewers and obtained an intraclass correlation coefficient of 0.92. There were no significant differences in intraluminal gas volume between menses and non-menses scans (p = 0.679). Even among the women with dysmenorrhea, there was no significant difference in the intraluminal gas volume between menses and non-menses (p = 0.753). During menstruation, the participants with dysmenorrhea had less intraluminal gas than participants without dysmenorrhea (p = 0.044). However, the correlation between the bowel gas volume and the pain symptoms were not significant (p > 0.05). Although increased bowel symptoms and bloating are reported in the women with dysmenorrhea during menses, our results do not support the hypothesis that increased intraluminal gas is a contributing factor. Although dietary treatment has been shown in other studies to improve menstrual pain, the mechanism responsible for abdominal symptoms requires further investigation. Our findings demonstrate that the intraluminal bowel gas volume measurements are feasible and are unaffected by menses under a controlled diet. The method described might prove helpful in future mechanistic studies in clarifying the role of intraluminal bowel gas in other conditions.
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spelling pubmed-91306982022-05-26 Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea Oh, Hyeyoung Ehrenpreis, Eli D. Tu, Frank F. Dillane, Katlyn E. Garrison, Ellen F. Leloudas, Nondas Prasad, Pottumarthi V. Hellman, Kevin M. Front Pain Res (Lausanne) Pain Research Women frequently report increased bloating, flatulence, and pain during the perimenstrual period. However, it is unknown whether women have more intraluminal gas during menses. To evaluate whether pain-free women or women with dysmenorrhea have different amounts of intraluminal bowel gas during the menses, we utilized magnetic resonance imaging (MRI) to determine colonic gas volumes throughout the menstrual cycle. To avoid dietary influence, the participants were instructed to avoid gas-producing foods before their scheduled MRI. We verified the measurement repeatability across the reviewers and obtained an intraclass correlation coefficient of 0.92. There were no significant differences in intraluminal gas volume between menses and non-menses scans (p = 0.679). Even among the women with dysmenorrhea, there was no significant difference in the intraluminal gas volume between menses and non-menses (p = 0.753). During menstruation, the participants with dysmenorrhea had less intraluminal gas than participants without dysmenorrhea (p = 0.044). However, the correlation between the bowel gas volume and the pain symptoms were not significant (p > 0.05). Although increased bowel symptoms and bloating are reported in the women with dysmenorrhea during menses, our results do not support the hypothesis that increased intraluminal gas is a contributing factor. Although dietary treatment has been shown in other studies to improve menstrual pain, the mechanism responsible for abdominal symptoms requires further investigation. Our findings demonstrate that the intraluminal bowel gas volume measurements are feasible and are unaffected by menses under a controlled diet. The method described might prove helpful in future mechanistic studies in clarifying the role of intraluminal bowel gas in other conditions. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9130698/ /pubmed/35634451 http://dx.doi.org/10.3389/fpain.2022.720141 Text en Copyright © 2022 Oh, Ehrenpreis, Tu, Dillane, Garrison, Leloudas, Prasad and Hellman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Oh, Hyeyoung
Ehrenpreis, Eli D.
Tu, Frank F.
Dillane, Katlyn E.
Garrison, Ellen F.
Leloudas, Nondas
Prasad, Pottumarthi V.
Hellman, Kevin M.
Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea
title Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea
title_full Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea
title_fullStr Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea
title_full_unstemmed Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea
title_short Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea
title_sort menstrual cycle variation in mri-based quantification of intraluminal gas in women with and without dysmenorrhea
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130698/
https://www.ncbi.nlm.nih.gov/pubmed/35634451
http://dx.doi.org/10.3389/fpain.2022.720141
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