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Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130765/ https://www.ncbi.nlm.nih.gov/pubmed/35633669 http://dx.doi.org/10.3389/fmicb.2022.883513 |
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author | Zhang, Xianyi Chen, Chan Xu, Yuzhong |
author_facet | Zhang, Xianyi Chen, Chan Xu, Yuzhong |
author_sort | Zhang, Xianyi |
collection | PubMed |
description | Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early and precise screening. Many studies have reported that Long non-coding RNAs (lncRNAs) play a regulatory role in gene expression in the host immune response against Mtb. Dysregulation of lncRNAs expression patterns associated with immunoregulatory pathways arose in mycobacterial infection. Meanwhile, host-induced lncRNAs regulate antibacterial processes such as apoptosis and autophagy to limit bacterial proliferation. In this review, we try to summarize the latest reports on how dysregulated expressed lncRNAs influence host immune response in tuberculosis infection. We also discuss their potential clinical prospects for tuberculosis diagnosis and development as molecular biomarkers. |
format | Online Article Text |
id | pubmed-9130765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91307652022-05-26 Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers Zhang, Xianyi Chen, Chan Xu, Yuzhong Front Microbiol Microbiology Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early and precise screening. Many studies have reported that Long non-coding RNAs (lncRNAs) play a regulatory role in gene expression in the host immune response against Mtb. Dysregulation of lncRNAs expression patterns associated with immunoregulatory pathways arose in mycobacterial infection. Meanwhile, host-induced lncRNAs regulate antibacterial processes such as apoptosis and autophagy to limit bacterial proliferation. In this review, we try to summarize the latest reports on how dysregulated expressed lncRNAs influence host immune response in tuberculosis infection. We also discuss their potential clinical prospects for tuberculosis diagnosis and development as molecular biomarkers. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9130765/ /pubmed/35633669 http://dx.doi.org/10.3389/fmicb.2022.883513 Text en Copyright © 2022 Zhang, Chen and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Zhang, Xianyi Chen, Chan Xu, Yuzhong Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
title | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
title_full | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
title_fullStr | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
title_full_unstemmed | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
title_short | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
title_sort | long non-coding rnas in tuberculosis: from immunity to biomarkers |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130765/ https://www.ncbi.nlm.nih.gov/pubmed/35633669 http://dx.doi.org/10.3389/fmicb.2022.883513 |
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